{"id":"W2560563727","doi":"10.1101/cshperspect.a028720","title":"Systems Chronobiology: Global Analysis of Gene Regulation in a 24-Hour Periodic World","year":2016,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Biology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Circadian rhythm; Suprachiasmatic nucleus; Chronobiology; Bacterial circadian rhythms; Oscillating gene; Light effects on circadian rhythm; Neuroscience; Circadian clock; Biological clock; CLOCK; Rhythm; Chromatin; Evolutionary biology; Gene; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004420936,0.0004299728,0.002367284,0.001575555,0.00005116867,0.0000226917,0.0004904416,0.0005025855,0.00006455038],"category_scores_gemma":[0.0003758317,0.0003558156,0.0004974314,0.00314873,0.0005178892,0.00006883663,0.0001283383,0.0003611895,0.00003489117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001548439,"about_ca_system_score_gemma":0.0003734097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001571221,"about_ca_topic_score_gemma":0.000216324,"domain_scores_codex":[0.9963259,0.000852806,0.0009260128,0.001230303,0.0001034773,0.0005615276],"domain_scores_gemma":[0.9981294,0.0004339908,0.0006302449,0.0006748752,0.00004609185,0.00008537769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004773944,0.0002961566,0.02040524,0.001619894,0.0006507928,0.00009210844,0.0003519493,0.00008705188,0.007233398,0.9550411,0.000009577846,0.01416506],"study_design_scores_gemma":[0.001790353,0.0002689355,0.1235146,0.01122777,0.002220366,0.0000293797,0.0001600886,0.0005170002,0.0008330549,0.00009505088,0.8573084,0.002035001],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007662153,0.9898393,0.0001097629,0.00002242686,0.0007267803,0.0008109343,0.0002656709,0.00004846263,0.0005145717],"genre_scores_gemma":[0.2534689,0.7460675,0.00003736609,0.000008583969,0.0001519921,0.0001468169,0.000003335497,0.00002531783,0.00009025139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.954946,"threshold_uncertainty_score":0.9998894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04519406327326946,"score_gpt":0.3347694590176331,"score_spread":0.2895753957443636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}