{"id":"W2560612526","doi":"10.1182/blood.v120.21.731.731","title":"MLN9708, a Novel, Investigational Oral Proteasome Inhibitor, in Patients with Relapsed or Refractory Light-Chain Amyloidosis (AL): Results of a Phase 1 Study","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Adverse effect; Proteasome inhibitor; Bortezomib; Pharmacodynamics; Refractory (planetary science); Phases of clinical research; Pharmacokinetics; Gastroenterology; Multiple myeloma; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002158273,0.0009790681,0.001630419,0.000291404,0.0003390341,0.0008226952,0.0006581687,0.0007999753,0.001559338],"category_scores_gemma":[0.0008720314,0.000422554,0.001215976,0.0004136587,0.0005448342,0.0007181875,0.00028558,0.001870779,0.0005814202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007482012,"about_ca_system_score_gemma":0.00106519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006449401,"about_ca_topic_score_gemma":0.001675465,"domain_scores_codex":[0.9994999,0.0002296035,0.00003565114,0.0000856749,0.00007042728,0.00007873443],"domain_scores_gemma":[0.9991492,0.0002206198,0.0001939446,0.00006584477,0.0000731251,0.0002972296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4753599,0.08539885,0.07129285,0.00160858,0.003660362,0.001411764,0.000869538,0.003907262,0.0775955,0.0002050688,0.006310902,0.2723794],"study_design_scores_gemma":[0.3100329,0.559252,0.1128619,0.0001188759,0.001917107,0.001722914,0.0002094541,0.003142919,0.005677972,0.0002467398,0.004750217,0.00006710139],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952388,0.002325474,0.0002539154,0.000204463,0.00002416143,0.0006022644,0.000533046,0.00003823526,0.0007795828],"genre_scores_gemma":[0.992473,0.00256565,0.001072222,0.0005990711,0.00009552804,0.0006963141,0.001719472,0.00002570558,0.000753033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002158273,"threshold_uncertainty_score":0.01141417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570155094874929,"score_gpt":0.2670340245809415,"score_spread":0.2513324736321922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}