{"id":"W2560615061","doi":"10.1177/2047487316682186","title":"Genetic invalidation of Lp-PLA<sub>2</sub> as a therapeutic target: Large-scale study of five functional Lp-PLA<sub>2</sub>-lowering alleles","year":2016,"lang":"en","type":"review","venue":"European Journal of Preventive Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Université de Genève; Helmholtz Zentrum München; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; NIHR Cambridge Biomedical Research Centre; European Commission; Regione Lombardia; Sydäntutkimussäätiö; British Heart Foundation; Münchner Zentrum für Gesundheitswissenschaften; Wellcome Trust; Foundation for Cardiovascular Research","keywords":"Medicine; Allele; Lipoprotein-associated phospholipase A2; Internal medicine; Genotyping; Randomized controlled trial; Gastroenterology; Genotype; Genetics; Gene; Lipoprotein; Biology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005397896,0.0007368125,0.004755676,0.0007011516,0.0001321682,0.00001767847,0.0004855768,0.0002773341,0.00007886445],"category_scores_gemma":[0.0003600184,0.0005332075,0.002988444,0.0003823225,0.000215361,0.0001372954,0.0002756344,0.001089398,0.00009164723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002617959,"about_ca_system_score_gemma":0.0009175538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004396946,"about_ca_topic_score_gemma":0.000003985966,"domain_scores_codex":[0.9885616,0.006272873,0.002737173,0.0007272696,0.001084054,0.0006170117],"domain_scores_gemma":[0.9942181,0.0003135376,0.003039245,0.0009145141,0.001187899,0.0003267453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007838921,0.0009488809,0.0005214438,0.006642945,0.02001873,0.00178379,0.001038386,0.0001902928,0.009193393,0.00001772457,0.0005774597,0.9582831],"study_design_scores_gemma":[0.03673433,0.03269668,0.1070396,0.06355034,0.04664384,0.02721904,0.004137315,0.00001627258,0.01017685,0.0004625891,0.6674973,0.003825834],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2232965,0.7622225,0.01048271,0.00002158931,0.001095567,0.00208695,0.0001151351,0.00002125942,0.0006577704],"genre_scores_gemma":[0.2089485,0.7885319,0.0001404189,0.0000488937,0.002009562,0.00003718354,0.00005583282,0.0001757581,0.00005195058],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9544572,"threshold_uncertainty_score":0.9997119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0279716611488948,"score_gpt":0.2861394838004894,"score_spread":0.2581678226515945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}