{"id":"W2560640491","doi":"10.1021/acs.molpharmaceut.6b00937","title":"Identification and Characterization of Trimethylamine-<i>N</i>-oxide Uptake and Efflux Transporters","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Hospital; London Health Sciences Centre; Western University","funders":"National Institute of General Medical Sciences; Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Health Canada; Crohn's and Colitis Canada","keywords":"Trimethylamine N-oxide; Efflux; Organic cation transport proteins; Chemistry; Transporter; Organic anion transporter 1; ATP-binding cassette transporter; In vivo; Abcg2; Flavin-containing monooxygenase; Choline; Carnitine; Biochemistry; Pharmacology; Biology; Monooxygenase; Trimethylamine; Metabolism; Cytochrome P450; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001505997,0.0001281419,0.0002789659,0.0003186514,0.0001403274,0.0003071032,0.000175195,0.0002813479,0.0005239767],"category_scores_gemma":[0.0002992663,0.00008944848,0.0002372561,0.0002619362,0.000116171,0.000189145,0.0001352229,0.0002032161,0.0002504674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756126,"about_ca_system_score_gemma":0.0001766774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00210057,"about_ca_topic_score_gemma":0.002037267,"domain_scores_codex":[0.9999306,0.000008318378,0.000007568944,0.00001909225,0.00001773591,0.00001666984],"domain_scores_gemma":[0.9998943,0.00001805356,0.00002248973,0.00001135291,0.00002814095,0.0000256415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002208544,0.00003475821,0.01031069,0.00003869989,0.00001555585,0.0001665899,0.00004700803,0.00006836413,0.9850504,0.0001039717,0.0000627006,0.003880429],"study_design_scores_gemma":[0.00006501686,0.0009986307,0.2896296,0.00003278538,0.0001186438,0.003511272,0.0003570481,0.006025355,0.6865526,0.0003713875,0.01230773,0.0000298594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995051,0.001224575,0.002284086,0.00008371251,0.00000616547,0.00002989582,0.0007087452,0.00001545266,0.0005963567],"genre_scores_gemma":[0.9879077,0.001144471,0.006026137,0.0001125875,0.00001501244,0.00004158863,0.00271325,0.00001740856,0.002021812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00210057,"threshold_uncertainty_score":0.004176736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409802352454545,"score_gpt":0.2736494011208321,"score_spread":0.2595513775962866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}