{"id":"W2560640491","doi":"10.1021/acs.molpharmaceut.6b00937","title":"Identification and Characterization of Trimethylamine-<i>N</i>-oxide Uptake and Efflux Transporters","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Hospital; London Health Sciences Centre; Western University","funders":"National Institute of General Medical Sciences; Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Health Canada; Crohn's and Colitis Canada","keywords":"Trimethylamine N-oxide; Efflux; Organic cation transport proteins; Chemistry; Transporter; Organic anion transporter 1; ATP-binding cassette transporter; In vivo; Abcg2; Flavin-containing monooxygenase; Choline; Carnitine; Biochemistry; Pharmacology; Biology; Monooxygenase; Trimethylamine; Metabolism; Cytochrome P450; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744543,0.0001170327,0.0002000475,0.00008696358,0.00002578336,0.000006357595,0.00003643022,0.000064755,0.00001441104],"category_scores_gemma":[0.000007842895,0.00008608908,0.00004655254,0.0001026641,0.00009450904,0.00006345261,0.00000564997,0.00005486286,0.000001611622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001204638,"about_ca_system_score_gemma":0.00002451261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.94436e-7,"about_ca_topic_score_gemma":4.425235e-7,"domain_scores_codex":[0.9991788,0.00001939224,0.000291528,0.0002011198,0.0001759761,0.0001332129],"domain_scores_gemma":[0.9995776,0.00001246732,0.00009311541,0.0001432983,0.00006408536,0.0001094538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025946,0.00004640553,0.002577298,0.0001745307,0.00005006847,0.00002260484,0.0001050427,1.156426e-7,0.9783456,0.0002664379,0.000001371753,0.01830792],"study_design_scores_gemma":[0.001766629,0.00003909428,0.07123491,0.0000936537,0.0002635259,0.00001671606,0.00001597928,0.00004600509,0.9238784,0.00005851182,0.002493218,0.00009337006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578241,0.0002908873,0.04065656,0.0007411828,0.00007578107,0.0002977763,0.00003009353,0.0000290624,0.00005452448],"genre_scores_gemma":[0.9977674,0.00104266,0.0004414005,0.0002018622,0.00001630045,0.000007783711,0.00003418442,0.0000222266,0.0004661087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06865761,"threshold_uncertainty_score":0.3510611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409802352454545,"score_gpt":0.2736494011208321,"score_spread":0.2595513775962866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}