{"id":"W2560661426","doi":"10.1136/annrheumdis-2016-210324","title":"Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Saskatchewan; University of Toronto","funders":"Sanofi; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; NHS Blood and Transplant; National Institute for Health and Care Research; National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Swedish Orphan Biovitrum; Servier; Bundesministerium für Bildung und Forschung; Arthritis Society; Cincinnati Children's Hospital Medical Center; Marcus Foundation; Sparks; Versus Arthritis; F. Hoffmann-La Roche; Medical Research Council; Celgene; Canadian Arthritis Network; National Human Genome Research Institute; Wellcome Trust; GlaxoSmithKline; Pfizer","keywords":"Medicine; Arthritis; Genome-wide association study; Genetic architecture; Single-nucleotide polymorphism; Juvenile; Disease; Bioinformatics; Genetics; Immunology; Genotype; Population; Biology; Internal medicine; Gene; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000674398,0.0002431883,0.001170199,0.00009382871,0.0001410483,0.00002327265,0.000377961,0.000130409,0.0001271298],"category_scores_gemma":[0.001694496,0.0001369246,0.0004229743,0.0001860182,0.0006841529,0.00007207514,0.0001649538,0.0001873804,0.00002009484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001468328,"about_ca_system_score_gemma":0.000407278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493504,"about_ca_topic_score_gemma":0.00004680176,"domain_scores_codex":[0.9968619,0.0003466412,0.001636505,0.0003524091,0.0004470555,0.0003554476],"domain_scores_gemma":[0.997409,0.0004079361,0.0007109498,0.001030895,0.0002452429,0.0001960002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002397534,0.0004992672,0.2131081,0.001130998,0.0004250916,0.000006407829,0.0005655737,0.000006752324,0.002272569,0.000687864,0.0006090918,0.7804486],"study_design_scores_gemma":[0.003559429,0.0006159997,0.9197935,0.0257288,0.0002514575,0.00009936921,0.0004644874,0.00009119439,0.001549282,0.04655737,0.0009345258,0.0003545562],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8756192,0.1193867,0.0003496001,0.003392159,0.000080051,0.0006912014,0.0003268323,0.00004312768,0.0001111378],"genre_scores_gemma":[0.9888688,0.01043301,0.00003953469,0.0003311647,0.00006496154,0.0001094019,0.000006084379,0.00004471665,0.000102317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.780094,"threshold_uncertainty_score":0.5583621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03964005571334484,"score_gpt":0.3211837784889096,"score_spread":0.2815437227755648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}