{"id":"W2560661426","doi":"10.1136/annrheumdis-2016-210324","title":"Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications","year":2016,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Saskatchewan; University of Toronto","funders":"Sanofi; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; NHS Blood and Transplant; National Institute for Health and Care Research; National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Swedish Orphan Biovitrum; Servier; Bundesministerium für Bildung und Forschung; Arthritis Society; Cincinnati Children's Hospital Medical Center; Marcus Foundation; Sparks; Versus Arthritis; F. Hoffmann-La Roche; Medical Research Council; Celgene; Canadian Arthritis Network; National Human Genome Research Institute; Wellcome Trust; GlaxoSmithKline; Pfizer","keywords":"Medicine; Arthritis; Genome-wide association study; Genetic architecture; Single-nucleotide polymorphism; Juvenile; Disease; Bioinformatics; Genetics; Immunology; Genotype; Population; Biology; Internal medicine; Gene; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005349582,0.0003591444,0.0004120108,0.0006131612,0.0003338461,0.0004534608,0.0002529467,0.0004086083,0.001019461],"category_scores_gemma":[0.00184967,0.0001231279,0.0003050498,0.0009688087,0.0007830786,0.0003454119,0.0003364161,0.0004146735,0.0001119928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265694,"about_ca_system_score_gemma":0.0005608561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510181,"about_ca_topic_score_gemma":0.002774708,"domain_scores_codex":[0.999589,0.000149309,0.00004819775,0.00008468898,0.00008401734,0.00004481472],"domain_scores_gemma":[0.9989484,0.0003299557,0.0005058883,0.00004337696,0.00008741854,0.00008501281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007750444,0.0001371012,0.9210973,0.000292709,0.0003490146,0.002615626,0.0002568419,0.000627007,0.02014906,0.00117717,0.0006420028,0.05188113],"study_design_scores_gemma":[0.0001032776,0.0003230881,0.9865377,0.000103357,0.0002134283,0.007851427,0.0003347649,0.0009072557,0.0008253862,0.001723738,0.001058569,0.00001801913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992344,0.004480698,0.0008190877,0.001093827,0.00002423249,0.0000162475,0.0001482742,0.00001891748,0.001054696],"genre_scores_gemma":[0.9974453,0.001187621,0.0009669391,0.0001011191,0.00006239727,0.000005717702,0.0001427015,0.000004714381,0.00008343525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510181,"threshold_uncertainty_score":0.003410399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03964005571334484,"score_gpt":0.3211837784889096,"score_spread":0.2815437227755648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}