{"id":"W2560673025","doi":"10.1523/jneurosci.1647-16.2016","title":"Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic<i>X. laevis</i>Models of Retinitis Pigmentosa","year":2016,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Rhodopsin; Histone deacetylase; Retinal degeneration; Biology; Valproic Acid; Pharmacology; Histone deacetylase inhibitor; Retinal; Cell biology; Chemistry; Biochemistry; Histone; Neuroscience; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002589742,0.0007269189,0.0007670058,0.0006454425,0.0003240677,0.0006172027,0.0005351094,0.0008169292,0.001369803],"category_scores_gemma":[0.0001596793,0.0003498431,0.0009378617,0.0002476736,0.0005812664,0.0004614734,0.0002483771,0.001977146,0.0003359219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006770322,"about_ca_system_score_gemma":0.0004173363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003307518,"about_ca_topic_score_gemma":0.004590864,"domain_scores_codex":[0.9995791,0.00005311539,0.00006483859,0.0001094086,0.00006673201,0.0001268318],"domain_scores_gemma":[0.9996613,0.00003667986,0.00008958102,0.00003098578,0.00003340832,0.0001480547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002124795,0.0004700443,0.0001795623,0.00007898832,0.00003618266,0.0000963932,0.00004894786,0.00009366096,0.9951579,0.00008725251,0.0001482898,0.001477967],"study_design_scores_gemma":[0.0002829806,0.00820007,0.003672466,0.00001667704,0.000129892,0.000183447,0.0001022769,0.0007194395,0.9848014,0.00006918344,0.001791624,0.00003061491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952183,0.001468486,0.0005089701,0.0002413596,0.0001426357,0.00005994763,0.000886785,0.0001772322,0.001296262],"genre_scores_gemma":[0.9899923,0.001726331,0.001861672,0.0001882186,0.00003736759,0.0001658957,0.001244511,0.00008300014,0.004700647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003307518,"threshold_uncertainty_score":0.006576538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900054726543699,"score_gpt":0.2635326441379912,"score_spread":0.2445320968725542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}