{"id":"W2560701831","doi":"10.15326/jcopdf.4.1.2016.0156","title":"The Effect of Alpha-1 Proteinase Inhibitor on Biomarkers of Elastin Degradation in Alpha-1 Antitrypsin Deficiency: An Analysis of the RAPID/RAPID Extension Trials","year":2016,"lang":"en","type":"article","venue":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"CSL Behring; Alpha-1 Foundation","keywords":"Placebo; Elastin; Desmosine; Alpha (finance); Proteinase inhibitor; Medicine; Internal medicine; Alpha 1-antitrypsin deficiency; Clinical trial; Gastroenterology; BETA (programming language); Surgery; Chemistry; Biochemistry; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008784928,0.0009026431,0.001761719,0.0002947182,0.0001841112,0.001018231,0.0002995535,0.0008202849,0.002664833],"category_scores_gemma":[0.006027734,0.0002523313,0.002841125,0.0003155566,0.000478852,0.0008738047,0.00032925,0.001724545,0.0002871808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801372,"about_ca_system_score_gemma":0.0003760133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002613532,"about_ca_topic_score_gemma":0.0006720177,"domain_scores_codex":[0.9958943,0.003216106,0.0002306729,0.0002919412,0.0002062964,0.0001606359],"domain_scores_gemma":[0.9929488,0.004772087,0.0009919468,0.0005476577,0.000263277,0.0004762616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8907638,0.0008181336,0.01477882,0.001669019,0.01314353,0.00007052806,0.00007786513,0.001063032,0.005421204,0.0002708863,0.0006142948,0.07130896],"study_design_scores_gemma":[0.4589345,0.255835,0.2133458,0.000837958,0.04758829,0.000649002,0.0001866888,0.004625881,0.00565245,0.001905881,0.01030929,0.0001292707],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.946404,0.04639517,0.001448105,0.0006483654,0.0002906806,0.0005464676,0.001078867,0.00006214663,0.003126265],"genre_scores_gemma":[0.993411,0.003363768,0.00101006,0.0001633208,0.000143122,0.0001673107,0.0003603288,0.00001148319,0.00136959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008784928,"threshold_uncertainty_score":0.04645973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080687757797126,"score_gpt":0.2646504393946708,"score_spread":0.2538435618166995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}