{"id":"W2560701831","doi":"10.15326/jcopdf.4.1.2016.0156","title":"The Effect of Alpha-1 Proteinase Inhibitor on Biomarkers of Elastin Degradation in Alpha-1 Antitrypsin Deficiency: An Analysis of the RAPID/RAPID Extension Trials","year":2016,"lang":"en","type":"article","venue":"Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"CSL Behring; Alpha-1 Foundation","keywords":"Placebo; Elastin; Desmosine; Alpha (finance); Proteinase inhibitor; Medicine; Internal medicine; Alpha 1-antitrypsin deficiency; Clinical trial; Gastroenterology; BETA (programming language); Surgery; Chemistry; Biochemistry; Pathology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001490006,0.000192825,0.0004608481,0.0001883432,0.0001499166,0.000014693,0.0004446422,0.00009929923,0.00002426578],"category_scores_gemma":[0.001739327,0.000086502,0.0005855925,0.0005076734,0.0003571116,0.00005487517,0.00009990551,0.00009454217,3.8791e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935322,"about_ca_system_score_gemma":0.0003913295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001464041,"about_ca_topic_score_gemma":0.00001125761,"domain_scores_codex":[0.996709,0.001483115,0.0009264938,0.000245725,0.0004596764,0.0001760277],"domain_scores_gemma":[0.9968438,0.0002882815,0.00194346,0.0005485387,0.0003163742,0.00005958029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00253774,0.0001655982,0.004502203,0.00004908761,0.0002967665,0.000001260251,0.00001422471,0.0002221219,0.9257638,0.00009093193,0.00002367821,0.06633257],"study_design_scores_gemma":[0.001253613,0.001623956,0.09456679,0.0003459158,0.0007374908,0.000008223705,0.0000531848,0.0003772783,0.9004636,0.0003861928,0.00007973311,0.0001039737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939329,0.004068098,0.0005192023,0.000144605,0.0004855434,0.0007473897,0.00008298855,0.000002002915,0.00001724139],"genre_scores_gemma":[0.9994826,0.0002582583,0.00003589313,0.000007355932,0.0001431373,0.00001881117,0.00002667721,0.00001384393,0.00001342759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09006459,"threshold_uncertainty_score":0.3527449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080687757797126,"score_gpt":0.2646504393946708,"score_spread":0.2538435618166995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}