{"id":"W2560717039","doi":"10.1056/nejmoa1612674","title":"Osimertinib or Platinum–Pemetrexed in <i>EGFR</i> T790M–Positive Lung Cancer","year":2016,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Cancer Research UK","keywords":"Osimertinib; T790M; Pemetrexed; Lung cancer; Medicine; Epidermal growth factor receptor; Oncology; Tyrosine-kinase inhibitor; Tyrosine kinase; Internal medicine; Cancer research; Chemotherapy; Cancer; Receptor; Erlotinib; Gefitinib; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001286827,0.000412137,0.001201824,0.0001857283,0.0002043582,0.0003827167,0.0003398095,0.000610714,0.003580995],"category_scores_gemma":[0.0008247945,0.0001598261,0.0008352208,0.0002161934,0.0003964552,0.0003227656,0.0002224134,0.0009544829,0.000288825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004231895,"about_ca_system_score_gemma":0.0007047662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003557167,"about_ca_topic_score_gemma":0.0009779428,"domain_scores_codex":[0.9996106,0.0002155227,0.00003093213,0.0000501608,0.00002520169,0.00006759827],"domain_scores_gemma":[0.9994757,0.0002148489,0.0001204458,0.0000216776,0.00001363459,0.0001538513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8975212,0.005489537,0.005272346,0.0009741485,0.0007692078,0.0001322217,0.00007833619,0.001335338,0.00883997,0.0002918156,0.001558911,0.07773703],"study_design_scores_gemma":[0.6681405,0.2984791,0.01739727,0.0001759827,0.001169278,0.0004135012,0.00006675264,0.001771485,0.005662452,0.0006939465,0.006007196,0.00002257397],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921331,0.003922001,0.0005059987,0.0003585881,0.0001845308,0.0007677682,0.0002438024,0.00003176925,0.001852503],"genre_scores_gemma":[0.9963527,0.001464141,0.0004036548,0.000290114,0.0001295415,0.0004828142,0.0002224593,0.000005731977,0.0006488969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003580995,"threshold_uncertainty_score":0.01197958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813295790068458,"score_gpt":0.3557524786313276,"score_spread":0.3376195207306431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}