{"id":"W2560738370","doi":"10.1164/rccm.201605-1027oc","title":"Neutrophil Elastase Activity Is Associated with Exacerbations and Lung Function Decline in Bronchiectasis","year":2017,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":414,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bayer HealthCare; Tenovus; Wellcome Trust; Alere; Cystic Fibrosis Foundation Therapeutics; GlaxoSmithKline; Queen's University Belfast; AstraZeneca; Queen's University; European Respiratory Society; Pfizer","keywords":"Bronchiectasis; Medicine; Sputum; Internal medicine; Desmosine; Neutrophil elastase; Gastroenterology; Pulmonary function testing; Elastase; Exacerbation; Prospective cohort study; Lung; Pathology; Elastin; Tuberculosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008884358,0.0002431955,0.0004563883,0.0005108421,0.000253805,0.0006345622,0.0003713639,0.0004325245,0.001344814],"category_scores_gemma":[0.002744685,0.0002243674,0.0002865523,0.0006287064,0.0002861548,0.0003449635,0.0004449619,0.0005580412,0.000190064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661102,"about_ca_system_score_gemma":0.0002106931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002504609,"about_ca_topic_score_gemma":0.00234478,"domain_scores_codex":[0.9993375,0.0002176061,0.00008613971,0.0001680136,0.0001109686,0.00007980217],"domain_scores_gemma":[0.9976561,0.0004239526,0.001175117,0.000194782,0.0002512004,0.000298834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002021021,0.0000130235,0.9988116,0.000007499377,0.00002965781,0.00004708032,0.00001580015,0.00001996581,0.0004236882,0.00000502687,0.000027652,0.0003968915],"study_design_scores_gemma":[0.000003981751,0.00005093279,0.9995458,0.000002569155,0.00001147948,0.0001654815,0.00002399729,0.0000833499,0.00006568358,0.000006143811,0.00003972877,9.505538e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991735,0.0003469135,0.0000663094,0.00003438165,0.000003081635,0.000007225517,0.0002173661,0.000001844176,0.0001493414],"genre_scores_gemma":[0.9995776,0.00004628035,0.0000535513,0.00001119884,0.00000567698,0.00000580399,0.0002041434,6.783471e-7,0.00009500703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002504609,"threshold_uncertainty_score":0.004980028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135829084167652,"score_gpt":0.3513376159056967,"score_spread":0.3299793250640202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}