{"id":"W2560791721","doi":"10.1371/journal.pgen.1006469","title":"Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Irish Research Council; Science Foundation Ireland; Banting Research Foundation","keywords":"Intraflagellar transport; Cilium; Rab; Biology; Ciliogenesis; Ciliopathies; Cell biology; Bardet–Biedl syndrome; Ciliopathy; GTPase; Dynein; Small GTPase; Basal body; Genetics; Microtubule; Gene; Flagellum; Phenotype; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005347481,0.0002337513,0.0002277693,0.0003924918,0.0002004165,0.0002836588,0.0001077589,0.0002895404,0.000805788],"category_scores_gemma":[0.00009299302,0.000127364,0.0002320047,0.0002747678,0.0001310915,0.0000940776,0.0002034927,0.0002476398,0.0004930616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001850213,"about_ca_system_score_gemma":0.0002027376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001568328,"about_ca_topic_score_gemma":0.003022311,"domain_scores_codex":[0.9999229,0.000002331446,0.000002725625,0.00003848775,0.00001920987,0.00001442681],"domain_scores_gemma":[0.9999434,0.00001178348,0.00001660805,0.000004786397,0.00001053698,0.00001296896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006572168,0.000007088444,0.003744071,0.00004295066,0.000008783146,0.00008574241,0.00001910554,0.0001010807,0.9932078,0.0000536283,0.0001418899,0.002522209],"study_design_scores_gemma":[0.00002187044,0.0002867992,0.5524066,0.00004352045,0.0001524922,0.001451261,0.0002324128,0.006762542,0.4178506,0.000189011,0.02055924,0.00004357486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860348,0.001609733,0.002506145,0.00006013573,0.00001732839,0.00001959845,0.008083409,0.000148666,0.001520246],"genre_scores_gemma":[0.9669977,0.001257166,0.005959016,0.0001769534,0.00001061629,0.00005660892,0.0195862,0.0001164232,0.005839221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568328,"threshold_uncertainty_score":0.003118396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009056721055943755,"score_gpt":0.1974663493868153,"score_spread":0.1884096283308715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}