{"id":"W2560791721","doi":"10.1371/journal.pgen.1006469","title":"Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Irish Research Council; Science Foundation Ireland; Banting Research Foundation","keywords":"Intraflagellar transport; Cilium; Rab; Biology; Ciliogenesis; Ciliopathies; Cell biology; Bardet–Biedl syndrome; Ciliopathy; GTPase; Dynein; Small GTPase; Basal body; Genetics; Microtubule; Gene; Flagellum; Phenotype; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151463,0.0002464712,0.0001624146,0.00003169004,0.0001816235,0.00003646849,0.0002628881,0.0001568016,0.00001951025],"category_scores_gemma":[0.00009418275,0.0001461663,0.00004859005,0.00007869535,0.0001931851,0.000007066962,0.0001259519,0.00006974314,0.00001283486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001833429,"about_ca_system_score_gemma":0.0002260348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001065118,"about_ca_topic_score_gemma":0.00001153804,"domain_scores_codex":[0.9987056,0.00004910157,0.0002148136,0.0004409227,0.0002767643,0.0003128359],"domain_scores_gemma":[0.9992921,0.00002983372,0.00009291019,0.0002971402,0.0001035174,0.0001844358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005418657,0.0001272382,0.004925737,0.00002189325,0.0001133477,0.000009677931,0.0001454551,0.000003880476,0.9940686,0.000003615209,0.0003951183,0.000131247],"study_design_scores_gemma":[0.001102106,0.0001792645,0.007127529,0.00009723022,0.00009090864,0.00002146941,0.0002910999,0.00001426083,0.9892675,0.00006130772,0.001459118,0.0002882469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962294,0.0009653186,0.001589517,0.0005323406,0.00004864317,0.0003477616,0.0001126105,0.00002873594,0.0001456333],"genre_scores_gemma":[0.9968812,0.0003026874,0.001408148,0.0003529576,0.00008194702,0.00004370304,0.0001207717,0.00004237179,0.000766172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004801144,"threshold_uncertainty_score":0.596049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009056721055943755,"score_gpt":0.1974663493868153,"score_spread":0.1884096283308715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}