{"id":"W2560807277","doi":"10.1182/blood.v124.21.4767.4767","title":"A Phase I Trial of Pomalidomide, Bortezomib (Velcade), and Dexamethasone (PVD) As Initial Treatment of AL Amyloidosis and Light Chain Deposition Disease","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pomalidomide; AL amyloidosis; Medicine; Bortezomib; Ixazomib; Multiple myeloma; Lenalidomide; Amyloidosis; Plasma cell dyscrasia; Plasma cell; Plasma cell neoplasm; Internal medicine; Pharmacology; Gastroenterology; Immunoglobulin light chain; Carfilzomib; Immunology; Plasmacytoma; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00141533,0.001161102,0.001424845,0.0004315046,0.0004843352,0.00117282,0.000834737,0.0009944523,0.002821278],"category_scores_gemma":[0.0008675283,0.0004511422,0.0009550388,0.0003923452,0.0009034227,0.0007239125,0.0003694065,0.003289935,0.0006853185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009014012,"about_ca_system_score_gemma":0.001337362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007352971,"about_ca_topic_score_gemma":0.001490386,"domain_scores_codex":[0.999582,0.0001825402,0.00002833191,0.0000911942,0.00003730568,0.00007857758],"domain_scores_gemma":[0.9993324,0.0001209901,0.00007068116,0.0000583319,0.0000418931,0.0003757206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7253652,0.1066072,0.005995144,0.0009224666,0.001117242,0.0007022545,0.0005137993,0.003054898,0.04404152,0.0005569754,0.00417458,0.1069486],"study_design_scores_gemma":[0.4876216,0.4976886,0.006496302,0.00004625639,0.0002390926,0.0004408189,0.00005056908,0.001025822,0.00338834,0.000200417,0.002779945,0.00002221886],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990931,0.0021418,0.0005224144,0.0004648037,0.000171646,0.002696207,0.0007324588,0.00007658941,0.002263085],"genre_scores_gemma":[0.9913011,0.001328901,0.001548494,0.0005844301,0.0001338324,0.001526913,0.001615366,0.00001748714,0.001943419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002821278,"threshold_uncertainty_score":0.009438097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055254313930264,"score_gpt":0.2905793429581517,"score_spread":0.2800267998188491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}