{"id":"W2560827813","doi":"10.1128/jvi.02151-16","title":"Histidine 375 Modulates CD4 Binding in HIV-1 CRF01_AE Envelope Glycoproteins","year":2016,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Glycoprotein; Serine; Infectivity; Histidine; Trimer; Amino acid; Plasma protein binding; Protein structure; Biochemistry; Virus; Virology; Phosphorylation; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111036,0.000193046,0.0001685683,0.00008426608,0.0001347229,0.0002012111,0.0002148005,0.0003017445,0.001009022],"category_scores_gemma":[0.0002056826,0.0001137159,0.000161902,0.00009146844,0.0002357082,0.0001371926,0.0001424897,0.0002960051,0.0002519322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004184132,"about_ca_system_score_gemma":0.000145781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002499817,"about_ca_topic_score_gemma":0.001664358,"domain_scores_codex":[0.9998734,0.00002316936,0.00001019599,0.00001775837,0.00003233852,0.0000430984],"domain_scores_gemma":[0.9999183,0.00002037487,0.00001934232,0.000006570879,0.000008520867,0.0000269026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002628419,0.00003951541,0.0006985208,0.00001421608,0.000006221536,0.0001023856,0.00002159887,0.0001074328,0.997942,0.00005537151,0.00001972401,0.000730238],"study_design_scores_gemma":[0.00008725555,0.001336572,0.05603693,0.00001308174,0.00004176976,0.0008204648,0.0001445553,0.00371822,0.9362237,0.00008711147,0.001467562,0.00002285664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996326,0.00006815919,0.00008003124,0.00001101982,0.000003316652,0.00000264008,0.0000206576,0.000003556589,0.0001780913],"genre_scores_gemma":[0.9995915,0.0000343801,0.00009000308,0.0000131946,0.000001370119,0.000001494258,0.0000430174,0.000002484432,0.0002225521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002499817,"threshold_uncertainty_score":0.004970551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487394009548865,"score_gpt":0.2552128538306855,"score_spread":0.2403389137351968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}