{"id":"W2560917069","doi":"10.1038/nm.4255","title":"SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia","year":2016,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ludwig-Maximilians-Universität München; Frankfurter Stiftung für krebskranke Kinder; José Carreras Leukämie-Stiftung; LOEWE-Zentrum für Translationale Medizin und Pharmakologie; Hilfe für krebskranke Kinder Frankfurt; Deutsche Forschungsgemeinschaft","keywords":"Cytarabine; Myeloid leukemia; Medicine; Biomarker; Leukemia; Myeloid; Oncology; Immunology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002082416,0.0003777165,0.0007923377,0.0007395231,0.00007926342,0.000009594834,0.0002355332,0.0006857274,0.0005014412],"category_scores_gemma":[0.001841319,0.0002041308,0.0001013804,0.0007300648,0.0005103131,0.00009077961,0.00009501562,0.0008904158,0.00002775825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001012605,"about_ca_system_score_gemma":0.0006988342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004773093,"about_ca_topic_score_gemma":0.00001490553,"domain_scores_codex":[0.9972096,0.0001833968,0.0004953857,0.0007149747,0.0006598927,0.0007367698],"domain_scores_gemma":[0.9971357,0.001477222,0.0001064274,0.0006295132,0.0002778723,0.0003732764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03180817,0.00007230376,0.008925333,0.0001745091,0.0003953168,0.0004086208,0.000911086,7.241917e-8,0.8545659,0.0002578782,0.05118608,0.05129468],"study_design_scores_gemma":[0.060767,0.004638308,0.3696312,0.002092496,0.0005364742,0.001174517,0.0003327422,0.001208726,0.0645975,0.003557941,0.490709,0.0007540871],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8340569,0.008883712,0.0008978215,0.1536177,0.0002472158,0.001637506,0.00008110889,0.00009258597,0.0004854722],"genre_scores_gemma":[0.9721929,0.001097347,0.002278987,0.01431427,0.0004583326,0.0001823532,0.0000359969,0.00009074016,0.009349117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7899684,"threshold_uncertainty_score":0.8324214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934886386599071,"score_gpt":0.335436191806298,"score_spread":0.3160873279403073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}