{"id":"W2560917069","doi":"10.1038/nm.4255","title":"SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia","year":2016,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ludwig-Maximilians-Universität München; Frankfurter Stiftung für krebskranke Kinder; José Carreras Leukämie-Stiftung; LOEWE-Zentrum für Translationale Medizin und Pharmakologie; Hilfe für krebskranke Kinder Frankfurt; Deutsche Forschungsgemeinschaft","keywords":"Cytarabine; Myeloid leukemia; Medicine; Biomarker; Leukemia; Myeloid; Oncology; Immunology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007394789,0.0003414207,0.0004565502,0.0009437001,0.0003729062,0.0009755944,0.0003179659,0.0005461825,0.002071679],"category_scores_gemma":[0.001471648,0.0002151446,0.0002015896,0.0008574369,0.0003201505,0.0004732258,0.0003672659,0.0006588431,0.0006053426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000559827,"about_ca_system_score_gemma":0.0002781699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002582057,"about_ca_topic_score_gemma":0.0003581864,"domain_scores_codex":[0.9995461,0.0001308732,0.00004316692,0.00007181129,0.0001492878,0.00005870952],"domain_scores_gemma":[0.9993353,0.0001618024,0.0002686281,0.00004701126,0.0001021453,0.00008505084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005095703,0.0003904771,0.4667531,0.000662072,0.0004706811,0.0006805921,0.0002124103,0.002074624,0.2792631,0.001655831,0.007379822,0.2353617],"study_design_scores_gemma":[0.0001979543,0.002500333,0.7174703,0.0001013414,0.0003348807,0.004757329,0.000435818,0.00748495,0.2325633,0.00248195,0.03161577,0.00005606238],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727545,0.01795701,0.002279636,0.00141622,0.0001638605,0.0000517831,0.00103217,0.0001540724,0.004190705],"genre_scores_gemma":[0.9942868,0.00131427,0.001890273,0.0001886026,0.0001067685,0.00002574492,0.0008271594,0.00001096872,0.001349473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071679,"threshold_uncertainty_score":0.00693047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01934886386599071,"score_gpt":0.335436191806298,"score_spread":0.3160873279403073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}