{"id":"W2560973135","doi":"10.1002/hep.28882","title":"Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay","year":2016,"lang":"en","type":"article","venue":"Hepatology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Yale Liver Center; National Institute on Alcohol Abuse and Alcoholism; Natural Sciences and Engineering Research Council of Canada; Yale University; University of California, Los Angeles; National Institutes of Health; National Institute of Environmental Health Sciences; Canadian Liver Foundation; U.S. Department of Veterans Affairs","keywords":"Biology; MEG3; Small heterodimer partner; RNA; Long non-coding RNA; Molecular biology; Transcription factor; Gene; Biochemistry; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841406,0.0002258731,0.0002263975,0.0001418974,0.00008797552,0.00002689245,0.0002536737,0.0002399342,0.0001332101],"category_scores_gemma":[0.00009708171,0.0001703156,0.00006369247,0.0001618419,0.0001116423,0.00001474968,0.0001845643,0.0001870721,0.0001674432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110052,"about_ca_system_score_gemma":0.0001447178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001911725,"about_ca_topic_score_gemma":0.000460357,"domain_scores_codex":[0.9982777,0.0001691043,0.0002411185,0.0006023218,0.0002089594,0.0005008106],"domain_scores_gemma":[0.9991121,0.00004063373,0.00008635688,0.0004080814,0.0001462937,0.0002064815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004557104,0.0000422531,0.0003919788,0.00002252606,0.00008861049,0.00005045481,0.0001193145,0.000005062163,0.9615806,0.00004453945,0.004355815,0.0328431],"study_design_scores_gemma":[0.000699891,0.0009277335,0.00009534867,0.00006944771,0.00002036527,0.0001126123,0.00006143704,0.0000517417,0.9651242,0.00002217866,0.03253498,0.0002800746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9169385,0.0003496087,0.08052766,0.0007595441,0.0002173902,0.000321128,0.00004829359,0.00002754043,0.0008102861],"genre_scores_gemma":[0.9971715,0.0004347742,0.0004657059,0.0004899341,0.000066623,0.00009834001,0.000043477,0.00004269711,0.00118699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08023291,"threshold_uncertainty_score":0.6945268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02626779757283673,"score_gpt":0.2872554162870804,"score_spread":0.2609876187142437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}