{"id":"W2560973135","doi":"10.1002/hep.28882","title":"Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay","year":2016,"lang":"en","type":"article","venue":"Hepatology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Yale Liver Center; National Institute on Alcohol Abuse and Alcoholism; Natural Sciences and Engineering Research Council of Canada; Yale University; University of California, Los Angeles; National Institutes of Health; National Institute of Environmental Health Sciences; Canadian Liver Foundation; U.S. Department of Veterans Affairs","keywords":"Biology; MEG3; Small heterodimer partner; RNA; Long non-coding RNA; Molecular biology; Transcription factor; Gene; Biochemistry; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319155,0.0003599293,0.0003008558,0.0001675422,0.0001857329,0.0002235824,0.0001910952,0.0003061543,0.002137624],"category_scores_gemma":[0.0001303853,0.0001779288,0.0005166208,0.0001243915,0.0002274195,0.0001386078,0.0003346711,0.0008488707,0.0006815127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164644,"about_ca_system_score_gemma":0.000189258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004764446,"about_ca_topic_score_gemma":0.0006754588,"domain_scores_codex":[0.9998496,0.00001559825,0.00001120476,0.00003978575,0.00003868632,0.0000451267],"domain_scores_gemma":[0.9999204,0.00001363367,0.0000201751,0.000009678382,0.000008506529,0.00002772579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155056,0.00001225421,0.0001103813,0.00002004941,0.000003843789,0.00003159438,0.000005547772,0.00001646422,0.9991817,0.00003345505,0.00005430544,0.000414864],"study_design_scores_gemma":[0.00002364385,0.0001819286,0.007193521,0.000004544496,0.00001542332,0.0001537469,0.0000220099,0.001035397,0.9896117,0.00007430313,0.001678899,0.000004857558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903339,0.001800433,0.004937225,0.000342173,0.000102732,0.00002659992,0.0008554675,0.0002756005,0.001325858],"genre_scores_gemma":[0.9926209,0.0005149867,0.001531396,0.0002095978,0.00001588816,0.00006183793,0.001176688,0.0000604398,0.003808185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002137624,"threshold_uncertainty_score":0.007151067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02626779757283673,"score_gpt":0.2872554162870804,"score_spread":0.2609876187142437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}