{"id":"W2560987280","doi":"10.1093/cvr/cvw211","title":"High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature","year":2016,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Israel Science Foundation; Canadian Diabetes Association","keywords":"LRP1; Heparanase; Diabetic cardiomyopathy; Programmed cell death; Endocrinology; Endothelial stem cell; Internal medicine; Cell biology; Biology; Apoptosis; Heart development; Cell; Medicine; LDL receptor; Cardiomyopathy; Lipoprotein; Heart failure; Biochemistry; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00345321,0.0003656443,0.0004777568,0.0002468216,0.00051194,0.00009468124,0.001250093,0.0003530664,0.00008040303],"category_scores_gemma":[0.0005180037,0.0002141267,0.0009813457,0.00060206,0.0002831272,0.00001624477,0.0004684266,0.0005542103,0.0004255728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177521,"about_ca_system_score_gemma":0.000375365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004097835,"about_ca_topic_score_gemma":0.00007792609,"domain_scores_codex":[0.9940284,0.001369489,0.0003067603,0.00111156,0.001828971,0.001354769],"domain_scores_gemma":[0.9964592,0.0001148389,0.000009955256,0.002044233,0.0009043007,0.0004674428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007711414,0.00006302824,0.00005270409,0.00006232531,0.0008814851,0.000146614,0.0001127011,0.0008936662,0.96808,0.0001219321,0.005275668,0.02353873],"study_design_scores_gemma":[0.001376699,0.0003358354,0.0002199379,0.00002220345,0.00003462323,0.00002364599,0.00005298026,0.00001571583,0.6613763,0.00003853499,0.3362477,0.0002558517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527459,0.02601827,0.01540207,0.001349581,0.0002290185,0.002230637,0.0008093093,0.00004242939,0.001172743],"genre_scores_gemma":[0.9894431,0.003999504,0.0001347091,0.0001023768,0.0006943312,0.0006504934,0.0000646421,0.00007531848,0.004835511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.330972,"threshold_uncertainty_score":0.8731833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04018376510359314,"score_gpt":0.2941198908356319,"score_spread":0.2539361257320388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}