{"id":"W2560987280","doi":"10.1093/cvr/cvw211","title":"High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature","year":2016,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Israel Science Foundation; Canadian Diabetes Association","keywords":"LRP1; Heparanase; Diabetic cardiomyopathy; Programmed cell death; Endocrinology; Endothelial stem cell; Internal medicine; Cell biology; Biology; Apoptosis; Heart development; Cell; Medicine; LDL receptor; Cardiomyopathy; Lipoprotein; Heart failure; Biochemistry; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000791228,0.0002021678,0.0001496214,0.00005991243,0.00006769836,0.000172026,0.00009283124,0.00015559,0.0007572803],"category_scores_gemma":[0.00004596229,0.0000535888,0.0001438256,0.00005914213,0.0001230784,0.0001125532,0.0001086406,0.000372409,0.0001622081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684165,"about_ca_system_score_gemma":0.0001087618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003241048,"about_ca_topic_score_gemma":0.0004738972,"domain_scores_codex":[0.9999392,0.000009473134,0.000006207421,0.00001282615,0.00001360013,0.00001876148],"domain_scores_gemma":[0.9999608,0.000006788612,0.000009491008,0.000006373748,0.000005351962,0.00001115762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006983088,0.00001356084,0.0001049558,0.00001563754,0.00000237833,0.00003057099,0.000008239778,0.00002385273,0.9990926,0.00004268232,0.00001477854,0.0005810385],"study_design_scores_gemma":[0.00001018608,0.0002438928,0.004544607,0.000002739559,0.000008550268,0.0001174114,0.00002027955,0.0004037958,0.9938991,0.0000214292,0.0007259059,0.000002046848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968161,0.0006509423,0.001524457,0.0000532929,0.000019413,0.00001083513,0.0001376267,0.00002860041,0.0007588523],"genre_scores_gemma":[0.9968278,0.0004380853,0.001022889,0.00004627922,0.000005906788,0.00001435612,0.0001949307,0.000006469729,0.001443365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007572803,"threshold_uncertainty_score":0.002533317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04018376510359314,"score_gpt":0.2941198908356319,"score_spread":0.2539361257320388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}