{"id":"W2560995308","doi":"10.1038/srep39551","title":"Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Medicine; Glomerulosclerosis; Kidney disease; Cardiac fibrosis; Renal function; Kidney; Internal medicine; Cardiology; Fibrosis; Nephrectomy; Cardiac function curve; Heart failure; Proteinuria; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002566157,0.0005126105,0.0006019197,0.0002773268,0.0001417443,0.0001906406,0.0001885808,0.0002775037,0.001106039],"category_scores_gemma":[0.0001232656,0.0001176348,0.0002980712,0.0001040457,0.0003209757,0.0003591397,0.0001816312,0.0008174217,0.0001249421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249368,"about_ca_system_score_gemma":0.0003159787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002018679,"about_ca_topic_score_gemma":0.0007368357,"domain_scores_codex":[0.9998883,0.00002504911,0.00001282716,0.00002029734,0.00002256531,0.00003089517],"domain_scores_gemma":[0.9998772,0.0000100116,0.00004676971,0.00001068759,0.00001290882,0.00004243819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002180118,0.0008851046,0.000316079,0.0002314531,0.00003338824,0.00006642844,0.00002485585,0.00009814501,0.987263,0.00009035999,0.00008934441,0.008721721],"study_design_scores_gemma":[0.0007670658,0.02496193,0.01397434,0.00005793877,0.0001430597,0.0005223862,0.0000935299,0.001633622,0.9543158,0.0002538133,0.003256838,0.00001958546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941688,0.002846724,0.001885891,0.0002057393,0.00006125012,0.000054403,0.0001257598,0.00008729839,0.0005641132],"genre_scores_gemma":[0.9938361,0.002172747,0.002400268,0.0001097976,0.00003600129,0.00006478989,0.0001751998,0.00001441109,0.001190532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106039,"threshold_uncertainty_score":0.003700137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006108895946715783,"score_gpt":0.2179962061990934,"score_spread":0.2118873102523776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}