{"id":"W2561001862","doi":"10.1093/nar/gkw1276","title":"BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Ontario Ministry of Research and Innovation; Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften; Genome Canada; Deutscher Akademischer Austauschdienst; Wellcome Trust; China Scholarship Council; GlaxoSmithKline; Cancer Prevention and Research Institute of Texas; Deutsche Krebshilfe; Pfizer; Eli Lilly and Company","keywords":"BRD4; Biology; Transcription factor; Enhancer; Bromodomain; FOXO1; Cell biology; Chromatin; Regulation of gene expression; Forkhead Transcription Factors; FOXO3; Epigenetics; FOXA2; Cancer research; Signal transduction; Protein kinase B; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005665848,0.00009116738,0.0001154112,0.0001251463,0.00004996693,0.00001710288,0.0002245362,0.0001630189,0.00005762321],"category_scores_gemma":[0.00022416,0.00006221753,0.0000337987,0.000127324,0.0002198922,0.00001245698,0.0003150124,0.0001140169,0.00001560116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000151966,"about_ca_system_score_gemma":0.00007700938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002694164,"about_ca_topic_score_gemma":0.000009580602,"domain_scores_codex":[0.9988083,0.0001504332,0.000192697,0.0003051989,0.0002737436,0.0002696364],"domain_scores_gemma":[0.9993871,0.00003499158,0.00003944609,0.0003390501,0.0001117222,0.00008773248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008370901,0.00006011402,0.001444713,0.0000228561,0.000004318406,0.000002828965,0.00003487951,6.649214e-8,0.9541937,0.0001504737,0.001662772,0.04233954],"study_design_scores_gemma":[0.0006736092,0.0003102477,0.002045488,0.00007023729,7.34574e-7,0.000002848761,0.00002836862,0.000005253446,0.9773266,0.0004211018,0.01903248,0.00008303462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968014,0.0002535223,0.0005965326,0.0004458508,0.00004508315,0.0002710743,0.00002323414,0.000007410896,0.001555843],"genre_scores_gemma":[0.9969505,0.0004644335,0.001360515,0.00001914077,0.0000941744,0.00002412721,0.000009066149,0.00001419808,0.001063867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0422565,"threshold_uncertainty_score":0.2537157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202795058548346,"score_gpt":0.296987101941577,"score_spread":0.2767075960867423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}