{"id":"W2561001862","doi":"10.1093/nar/gkw1276","title":"BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Ontario Ministry of Research and Innovation; Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften; Genome Canada; Deutscher Akademischer Austauschdienst; Wellcome Trust; China Scholarship Council; GlaxoSmithKline; Cancer Prevention and Research Institute of Texas; Deutsche Krebshilfe; Pfizer; Eli Lilly and Company","keywords":"BRD4; Biology; Transcription factor; Enhancer; Bromodomain; FOXO1; Cell biology; Chromatin; Regulation of gene expression; Forkhead Transcription Factors; FOXO3; Epigenetics; FOXA2; Cancer research; Signal transduction; Protein kinase B; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001222003,0.0002704237,0.0002480508,0.0002963337,0.0001615672,0.0002283743,0.0001527331,0.0001777272,0.001398113],"category_scores_gemma":[0.00007614429,0.0001316285,0.0002761337,0.0001712928,0.000183096,0.0001233915,0.0002339201,0.0003594082,0.0005304018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003705273,"about_ca_system_score_gemma":0.0002738817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006204,"about_ca_topic_score_gemma":0.001300861,"domain_scores_codex":[0.9998931,0.00001626458,0.000009923268,0.00002117061,0.00002969562,0.00002989703],"domain_scores_gemma":[0.9999533,0.000005207324,0.00001207253,0.000006674213,0.000007203625,0.00001560874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001218916,0.00002445944,0.00008583454,0.00003323493,0.000002662099,0.00001979362,0.000005260365,0.00002869438,0.998955,0.00004596553,0.00002985901,0.0006472123],"study_design_scores_gemma":[0.000026529,0.0001501765,0.003200341,0.000003948539,0.000007535318,0.00006427869,0.00001328633,0.000534712,0.9932636,0.00004172515,0.00269151,0.000002329018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895235,0.003147281,0.003126498,0.000223187,0.00005599387,0.00004095169,0.0007325623,0.0002607333,0.002889331],"genre_scores_gemma":[0.9857717,0.001656585,0.002643732,0.0001348745,0.00001392143,0.00005413133,0.001269103,0.00003803138,0.008417968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398113,"threshold_uncertainty_score":0.004677176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202795058548346,"score_gpt":0.296987101941577,"score_spread":0.2767075960867423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}