{"id":"W2561211859","doi":"10.1039/c6sc03862j","title":"An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo","year":2016,"lang":"en","type":"article","venue":"Chemical Science","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Austrian Science Fund","keywords":"In vivo; Prodrug; Oxaliplatin; Albumin; Pharmacology; Chemistry; Cancer research; Cancer; Medicine; Biochemistry; Internal medicine; Biology; Colorectal cancer; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426205,0.000300433,0.0002256656,0.0001498263,0.00006589668,0.0001745267,0.0001718278,0.0002347601,0.0004384964],"category_scores_gemma":[0.0001155464,0.00009340957,0.00007813286,0.0001249816,0.0001324735,0.0001436548,0.0001016695,0.0002546306,0.0001604739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241153,"about_ca_system_score_gemma":0.0001754509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004998206,"about_ca_topic_score_gemma":0.0005352561,"domain_scores_codex":[0.9999424,0.000008908333,0.000005467974,0.0000174429,0.00001153348,0.00001413432],"domain_scores_gemma":[0.9999632,0.000006632851,0.000007787871,0.000003943255,0.000006665374,0.00001186241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001859872,0.0000463659,0.00007325409,0.00004302822,0.000004721521,0.00007373328,0.00002092567,0.0002940243,0.9937809,0.0002161824,0.00007929211,0.00518161],"study_design_scores_gemma":[0.0000403417,0.0009814234,0.0007312602,0.000001564998,0.00001372305,0.0001993414,0.000003101463,0.0009353531,0.9950305,0.00002722216,0.002032452,0.000003635267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749299,0.001400908,0.02062604,0.000126257,0.00006273776,0.0001167651,0.0001933115,0.0002633277,0.002280715],"genre_scores_gemma":[0.9893959,0.000356976,0.006933154,0.00003996556,0.000007517667,0.00002180685,0.0001641847,0.00002811276,0.00305231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004998206,"threshold_uncertainty_score":0.001749754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007529460877879998,"score_gpt":0.2367692967195862,"score_spread":0.2292398358417062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}