{"id":"W2561219738","doi":"10.1002/cbic.201600561","title":"A Specific Activity‐Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease","year":2016,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Krabbe disease; Enzyme; Glycolipid; Fluorophore; Biology; Biochemistry; Disease; Chemistry; Leukodystrophy; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000368407,0.0002787274,0.0003166705,0.0002011135,0.00009420468,0.00005280967,0.0003475753,0.0001065296,0.0001991405],"category_scores_gemma":[0.0004450335,0.0001631482,0.0001569786,0.0007299855,0.000174631,0.00007979483,0.0001546967,0.000275287,0.0004430875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005207987,"about_ca_system_score_gemma":0.0002714594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000521729,"about_ca_topic_score_gemma":0.0000088565,"domain_scores_codex":[0.9975547,0.00009054259,0.0002497857,0.0006274531,0.000774844,0.0007026775],"domain_scores_gemma":[0.9981326,0.0001869649,0.00005543538,0.0009181398,0.0001546854,0.0005521784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00122308,0.001034176,0.01006789,0.0001228582,0.00002198066,0.0001591565,0.0002018926,0.000003884998,0.9577174,0.00004397318,0.004622177,0.02478152],"study_design_scores_gemma":[0.002498445,0.0001570793,0.1835465,0.0002700081,0.00001806876,0.000003996844,0.0001154877,0.00008392877,0.8071812,0.00003930001,0.005837076,0.0002488866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837005,0.0008075925,0.0009227745,0.01095188,0.0001056905,0.001472312,0.00002834432,0.00008721366,0.00192368],"genre_scores_gemma":[0.9968596,0.00003749135,0.0001269741,0.000665946,0.0001828148,0.0003441702,0.00001026039,0.00005708519,0.00171573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1734787,"threshold_uncertainty_score":0.6652991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147670295021494,"score_gpt":0.2915062302446725,"score_spread":0.2600295272944576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}