{"id":"W2561439902","doi":"10.1158/1538-7445.am2015-2465","title":"Abstract 2465: Targeting HER2-positive brain metastases by incorporating the brain-penetrant Angiopep-2 peptide to an anti-HER2 antibody and anti-HER2 antibody drug conjugate","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Angiochem (Canada)","funders":"","keywords":"Transcytosis; In vitro; Monoclonal antibody; Antibody; Cancer research; Docetaxel; Chemistry; Pharmacology; Trastuzumab; Blood–brain barrier; Receptor tyrosine kinase; Receptor; Biology; Cancer; Biochemistry; Immunology; Medicine; Internal medicine; Central nervous system; Breast cancer; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007473818,0.0002724308,0.0001148324,0.0001347073,0.00006381971,0.0001812226,0.0001371856,0.0002141137,0.001254358],"category_scores_gemma":[0.00005588583,0.00009470776,0.0001134644,0.00006040113,0.00009742911,0.0001457489,0.0001195921,0.0002303178,0.0003435591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002198037,"about_ca_system_score_gemma":0.0001483992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000271697,"about_ca_topic_score_gemma":0.0003745711,"domain_scores_codex":[0.9999484,0.000008893719,0.000003238053,0.000009920771,0.00001749293,0.00001210817],"domain_scores_gemma":[0.9999697,0.000003984645,0.000009598484,0.000002313369,0.000004036712,0.00001025526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005990832,0.00005896209,0.00009491442,0.00003056735,0.000006339475,0.0001050498,0.000006004556,0.0002501535,0.996342,0.0002208028,0.0001177823,0.002707646],"study_design_scores_gemma":[0.00005339104,0.0008418512,0.001242362,0.000003326382,0.00001350729,0.0004742782,0.000003134774,0.001527327,0.989996,0.00003627263,0.005804332,0.000004308214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852383,0.001128551,0.008575859,0.0001006458,0.00006393433,0.0001761617,0.0001535048,0.000121539,0.004441741],"genre_scores_gemma":[0.9848299,0.0005711562,0.00785162,0.00009139161,0.00002188645,0.00008072269,0.0001854619,0.0000156381,0.00635235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254358,"threshold_uncertainty_score":0.004196227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06135352249237156,"score_gpt":0.4195565844316866,"score_spread":0.3582030619393151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}