{"id":"W2561468700","doi":"10.1158/1538-7445.am2015-lb-240","title":"Abstract LB-240: SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Lung cancer; Cancer research; Gene knockdown; Cancer; Gefitinib; Acquired resistance; Biology; Medicine; Epidermal growth factor receptor; Oncology; Internal medicine; Genetics; Cell culture","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009069447,0.0001468102,0.0001938739,0.000135703,0.0000898209,0.00007818503,0.0001585108,0.0001452623,0.00004281058],"category_scores_gemma":[0.0004030008,0.0001280333,0.00002528933,0.0001584874,0.000140682,0.00001191633,0.0002586173,0.0002274555,0.000001649192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000110606,"about_ca_system_score_gemma":0.0004426099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002113443,"about_ca_topic_score_gemma":0.0009991466,"domain_scores_codex":[0.9983614,0.0001712911,0.0002084488,0.0004868474,0.0003496877,0.0004223144],"domain_scores_gemma":[0.9990801,0.00008691939,0.00003612156,0.0002665003,0.000233198,0.0002971525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009875855,0.0000240258,0.01531363,0.00009718903,0.00001747897,0.000007924897,0.0004117117,0.0002823983,0.9540483,0.000003682718,0.02238592,0.006420203],"study_design_scores_gemma":[0.002784264,0.0003237805,0.01160835,0.0006129058,0.00001271882,0.000007499938,0.0008375103,0.0002489333,0.925985,0.000104208,0.05709378,0.0003809945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720297,0.02625118,0.00001917357,0.0007180724,0.0001203791,0.0003751713,0.00006662501,0.000009444389,0.0004102471],"genre_scores_gemma":[0.9955105,0.002803179,0.0001368427,0.0001470618,0.0003447938,0.0003294438,0.00001179652,0.00002732931,0.0006890573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03470787,"threshold_uncertainty_score":0.5221046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05896258463966057,"score_gpt":0.415770564107877,"score_spread":0.3568079794682164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}