{"id":"W2561489460","doi":"10.1182/blood.v114.22.644.644","title":"Safety and Efficacy of Subcutaneous-Administered Omacetaxine Mepesuccinate in Imatinib-Resistant Chronic Myeloid Leukemia (CML) Patients Who Harbor the Bcr- Abl T315I Mutation–Results of An Ongoing Multicenter Phase 2/3 Study.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Imatinib; Imatinib mesylate; Dasatinib; Adverse effect; Gastroenterology; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008006789,0.0004627429,0.0008987054,0.0001492086,0.0001891057,0.0003859953,0.0002925695,0.0005345672,0.001221277],"category_scores_gemma":[0.0007734303,0.0001908563,0.0005487652,0.0002454167,0.0003913838,0.0004638662,0.0001453992,0.001061083,0.0003264722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003127717,"about_ca_system_score_gemma":0.0004400675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000349717,"about_ca_topic_score_gemma":0.0006851837,"domain_scores_codex":[0.9997488,0.0001336332,0.00001995912,0.00003129982,0.00003240339,0.00003402888],"domain_scores_gemma":[0.9994678,0.0001247062,0.0001843033,0.00003905686,0.00002667275,0.0001574523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5583626,0.03172605,0.04493333,0.00085181,0.001185678,0.0006105773,0.0003913443,0.002790289,0.1478279,0.0001757355,0.002279551,0.2088652],"study_design_scores_gemma":[0.1694957,0.7071801,0.1032831,0.00005291484,0.0005757928,0.0009236949,0.00009266055,0.002232844,0.01351809,0.000127587,0.002492889,0.0000245863],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982322,0.0007790158,0.0001373317,0.00006724201,0.00001135489,0.0001939996,0.0001722364,0.00001248589,0.0003942566],"genre_scores_gemma":[0.9981951,0.0004286224,0.0002987276,0.0001157848,0.00003990307,0.0001707708,0.0004882375,0.000006343022,0.0002565941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221277,"threshold_uncertainty_score":0.004234493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030782127058177,"score_gpt":0.2801597147102233,"score_spread":0.2698518934396416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}