{"id":"W2561561024","doi":"10.1002/1873-3468.12550","title":"Adipocyte‐specific disruption of mouse <i>Cnot3</i> causes lipodystrophy","year":2016,"lang":"en","type":"letter","venue":"FEBS Letters","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Occupational Cancer Research Centre; McGill University Health Centre","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Adipose tissue; Lipodystrophy; Internal medicine; White adipose tissue; Endocrinology; PRDM16; Hyperinsulinemia; Adipocyte; Leptin; Insulin resistance; Adipose tissue macrophages; Inflammation; Biology; Brown adipose tissue; Obesity; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005369241,0.0003429866,0.0003029189,0.000104459,0.00005795313,0.00002835464,0.0002735846,0.0006859074,0.0001211549],"category_scores_gemma":[0.00001287563,0.0002814451,0.0002587293,0.00006203004,0.0001594346,0.000006249543,0.0000806099,0.0004171822,0.00008739747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003520722,"about_ca_system_score_gemma":0.00002448282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001501702,"about_ca_topic_score_gemma":0.000003050752,"domain_scores_codex":[0.9984511,0.00007583375,0.0003070279,0.0005477418,0.0002556636,0.0003626132],"domain_scores_gemma":[0.9989144,0.0000138223,0.0002587047,0.0007034314,0.00006534778,0.00004432974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004327365,0.000003411004,0.00003806593,0.00003517717,0.00006359276,0.00001592581,0.000005708941,0.000001759638,0.4805761,0.000003219341,0.5184987,0.0007150926],"study_design_scores_gemma":[0.0003032669,0.0001418069,0.0001082803,0.00003522665,0.000046008,0.00002235856,0.000002745283,2.404894e-7,0.1234608,0.000006845104,0.8755732,0.0002992308],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.464206,0.001927159,0.003711636,0.52105,0.0052588,0.0008687215,0.001072734,0.0001284787,0.001776516],"genre_scores_gemma":[0.03943941,0.0007347281,0.0007300153,0.9176428,0.02907361,0.00004601648,0.003002327,0.0002980395,0.009033015],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.4247666,"threshold_uncertainty_score":0.9999638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007325987961072489,"score_gpt":0.2011420467000136,"score_spread":0.1938160587389411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}