{"id":"W2561643684","doi":"10.1182/blood.v108.11.2240.2240","title":"Molecular and Pharmacologic Suppression of MAPK Activity Rescues Differentiation of BCR/ABL+ Myeloid Progenitors by Releasing C/EBPa from the Inhibitory Effect of hnRNP E2.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"K562 cells; ABL; breakpoint cluster region; Progenitor cell; Chronic myelogenous leukemia; Myeloid; Biology; Molecular biology; Cancer research; Myeloid leukemia; Leukemia; Stem cell; Cell biology; Immunology; Receptor; Signal transduction; Tyrosine kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019391,0.0003543372,0.0001599728,0.0001444162,0.0001399351,0.0002000266,0.0002428436,0.000215913,0.001854143],"category_scores_gemma":[0.00006166966,0.0001192025,0.0001898743,0.0001110461,0.00023474,0.0001088608,0.0001508561,0.0005909396,0.0005216733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000202522,"about_ca_system_score_gemma":0.0001972887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004969105,"about_ca_topic_score_gemma":0.0009529623,"domain_scores_codex":[0.9999001,0.00001657062,0.00001111421,0.00001487994,0.00002499876,0.0000322853],"domain_scores_gemma":[0.9999356,0.000009761726,0.00001536465,0.000008276473,0.000004336241,0.00002662006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489006,0.00006755712,0.00003461889,0.00002632825,0.000003348097,0.00003337613,0.000005040619,0.00004928882,0.9988946,0.00009040143,0.00004117376,0.000605364],"study_design_scores_gemma":[0.00005086422,0.0004376788,0.001540256,0.00000530439,0.000009598215,0.0002205164,0.00001624269,0.000520569,0.9944525,0.00003814797,0.002705431,0.000002828207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943242,0.000984241,0.001408118,0.0001205027,0.0000394486,0.00004751747,0.0007186828,0.0001308228,0.002226425],"genre_scores_gemma":[0.9932613,0.0006907682,0.001451985,0.00005245851,0.00001161942,0.00006925171,0.0009869155,0.00002467934,0.003451026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001854143,"threshold_uncertainty_score":0.006202757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005215759300502526,"score_gpt":0.2390252895310981,"score_spread":0.2338095302305955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}