{"id":"W2561698087","doi":"10.1038/ja.2016.151","title":"Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases","year":2016,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bio-oriented Technology Research Advancement Institution; University of Tsukuba; Institute for Protein Research, Osaka University; University of Toronto; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Response regulator; Biology; Histidine kinase; Histidine; Virulence; Kinase; Escherichia coli; Biochemistry; Mutagenesis; Phosphorylation; Signal transduction; Binding site; Mutation; Enzyme; Gene; Bacterial protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006481674,0.0001863487,0.000159967,0.00007479329,0.0001185399,0.0001915734,0.0001325156,0.0002429668,0.0007898836],"category_scores_gemma":[0.000139919,0.00006132494,0.0001110133,0.0000577148,0.0001412393,0.0002122716,0.0001952861,0.0003152172,0.0003093536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133555,"about_ca_system_score_gemma":0.0001333995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002279631,"about_ca_topic_score_gemma":0.0004080058,"domain_scores_codex":[0.9999142,0.00001699736,0.000005170837,0.00001766068,0.00001628718,0.00002968123],"domain_scores_gemma":[0.9999145,0.00001544674,0.00002497479,0.000008018389,0.000007458488,0.00002947409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001491064,0.00001145841,0.0004103215,0.00001258959,0.000002427388,0.000102411,0.000006237905,0.00004549437,0.9978234,0.00008646053,0.00002235171,0.00132774],"study_design_scores_gemma":[0.00002200972,0.0003204019,0.007073813,0.000005348566,0.000008692574,0.0007889019,0.00003054264,0.0006529881,0.9885489,0.00007077881,0.002472465,0.000005048553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971067,0.000673709,0.000873695,0.00004474058,0.00001880593,0.00000937102,0.00003536322,0.00001762272,0.001220005],"genre_scores_gemma":[0.9980489,0.0002247229,0.0007430189,0.00003724517,0.000007206868,0.000004718152,0.0001003889,0.00000412806,0.0008296369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007898836,"threshold_uncertainty_score":0.002642393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545409698070349,"score_gpt":0.2408423948729411,"score_spread":0.2253882978922376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}