{"id":"W2561747224","doi":"10.1158/1538-7445.am2015-1958","title":"Abstract 1958: Interaction between keratin intermediate filament proteins K8/18 and cancer related signal transduction proteins in epithelial cells","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Keratin 8; Intermediate filament; Keratin; Epithelial–mesenchymal transition; Cell biology; Protein kinase B; Biology; Vimentin; PI3K/AKT/mTOR pathway; Gene knockdown; Signal transduction; Cell; Cancer research; Wnt signaling pathway; Keratin 14; Cytoskeleton; Cancer; Cell culture; Immunology; Metastasis; Genetics; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008954936,0.0002695976,0.0001624603,0.0001907526,0.0002210955,0.0001551042,0.0001612022,0.0002521747,0.002546594],"category_scores_gemma":[0.00008571001,0.0000832846,0.0003752584,0.0001710735,0.0001281356,0.0001855379,0.0001725322,0.0003426807,0.0007969189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370944,"about_ca_system_score_gemma":0.0001250975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004486535,"about_ca_topic_score_gemma":0.0003062594,"domain_scores_codex":[0.9999193,0.00001199632,0.000007271753,0.00001658402,0.00001800313,0.00002685201],"domain_scores_gemma":[0.9999629,0.000005373341,0.00001062766,0.000002547824,0.000006418216,0.00001209539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003040021,0.00004418526,0.0006600777,0.0001393881,0.00001634001,0.0002043911,0.00001784441,0.00004304423,0.9960544,0.0001655953,0.0002137601,0.002136854],"study_design_scores_gemma":[0.00005336686,0.0005274715,0.01808542,0.00003234253,0.00006421404,0.001146915,0.00008822849,0.001303331,0.9638099,0.0002218787,0.01465673,0.00001026622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809892,0.01034176,0.003764561,0.000324886,0.0001943854,0.00004851248,0.0007295178,0.00009513368,0.003512008],"genre_scores_gemma":[0.9890387,0.002932187,0.002213487,0.0001221085,0.00003443253,0.00005657956,0.001049311,0.00001437955,0.004538828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002546594,"threshold_uncertainty_score":0.008519232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06579935596783996,"score_gpt":0.3767531071743827,"score_spread":0.3109537512065427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}