{"id":"W2561747224","doi":"10.1158/1538-7445.am2015-1958","title":"Abstract 1958: Interaction between keratin intermediate filament proteins K8/18 and cancer related signal transduction proteins in epithelial cells","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Keratin 8; Intermediate filament; Keratin; Epithelial–mesenchymal transition; Cell biology; Protein kinase B; Biology; Vimentin; PI3K/AKT/mTOR pathway; Gene knockdown; Signal transduction; Cell; Cancer research; Wnt signaling pathway; Keratin 14; Cytoskeleton; Cancer; Cell culture; Immunology; Metastasis; Genetics; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423799,0.0001711642,0.0002013965,0.0001972145,0.0001074965,0.00006024901,0.0002283778,0.0003076835,0.0003514461],"category_scores_gemma":[0.00006690021,0.0001603002,0.000052271,0.0002453291,0.0002719405,0.00001709259,0.0001392943,0.0007650608,0.00002675228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504319,"about_ca_system_score_gemma":0.000570516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135164,"about_ca_topic_score_gemma":0.0005277185,"domain_scores_codex":[0.9977402,0.0004058502,0.0003204671,0.000575729,0.0003992615,0.0005584856],"domain_scores_gemma":[0.9991859,0.00003133723,0.00006438877,0.0002395495,0.0002434639,0.0002353691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000491157,0.0001003029,0.0041127,0.00006031502,0.00007043269,0.00002217041,0.000473534,0.0000499413,0.9681122,0.000004664162,0.0006695862,0.02583304],"study_design_scores_gemma":[0.001429192,0.0006374408,0.006248388,0.0001025544,0.000007959686,0.000007586767,0.0003227773,0.00007175269,0.9820772,0.0001005985,0.008796177,0.0001983155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962398,0.001394188,0.0000498239,0.0004985487,0.0001928071,0.00117488,0.00007005731,0.0000150577,0.0003648597],"genre_scores_gemma":[0.9960082,0.001543177,0.00005685518,0.00001701445,0.0005921311,0.0008464802,0.0001147586,0.00003092221,0.0007904624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02563473,"threshold_uncertainty_score":0.6536853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06579935596783996,"score_gpt":0.3767531071743827,"score_spread":0.3109537512065427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}