{"id":"W2561771176","doi":"10.1021/acs.jmedchem.6b01516","title":"Design and Synthesis of a Series of <scp>l</scp>-<i>trans</i>-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2<i>S</i>,4<i>R</i>)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Seventh Framework Programme; Danish Agency for Science and Higher Education; Fonds de Recherche du Québec - Santé; Danmarks Frie Forskningsfond; Lundbeckfonden; Københavns Universitet","keywords":"Chemistry; Ionotropic effect; Stereochemistry; Glutamate receptor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351803,0.0004750062,0.0003730546,0.0001729885,0.0001367601,0.000276473,0.0004774193,0.0003262706,0.00132846],"category_scores_gemma":[0.0001490542,0.0001986521,0.0003185767,0.0002585684,0.0001412641,0.0002604145,0.0002018681,0.0005026667,0.0006055739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373124,"about_ca_system_score_gemma":0.000340048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004030062,"about_ca_topic_score_gemma":0.0007439124,"domain_scores_codex":[0.9998966,0.00001650658,0.00001460615,0.00002117438,0.00002716144,0.00002387561],"domain_scores_gemma":[0.9999176,0.000004578355,0.0000285712,0.000007614189,0.00001834649,0.00002324245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002031477,0.00008217895,0.00008592739,0.000287817,0.00002287029,0.0002089,0.00002859027,0.001268908,0.9893655,0.0004564265,0.0002447064,0.007745115],"study_design_scores_gemma":[0.0001727599,0.002411807,0.00064087,0.00002263224,0.0000520192,0.0004433949,0.00002231845,0.00150775,0.9778656,0.0001150731,0.01672088,0.0000249879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489217,0.008244522,0.03036444,0.0003664711,0.0001674222,0.0006311967,0.001686302,0.0003254788,0.009292451],"genre_scores_gemma":[0.9512354,0.008489071,0.03179451,0.0002673994,0.00004946492,0.000346776,0.0019973,0.00005549966,0.005764566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132846,"threshold_uncertainty_score":0.004444182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06172114399891915,"score_gpt":0.3152889892153868,"score_spread":0.2535678452164677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}