{"id":"W2561778731","doi":"10.1016/s1525-0016(16)33394-9","title":"586. Dimerization Inhibition of HIV-1 RNA by 2’-Deoxy-2’-fluoro-beta-D-arabinose Nucleic Acid (2’-FANA) Modified Antisense Oligonucleotides Results in Potential Inhibition of Viral Expression","year":2016,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"RNA; Nucleic acid; Oligonucleotide; RNase H; Biology; Base pair; DNA; Molecular biology; Antisense RNA; Antisense therapy; RNase P; Chemistry; Biochemistry; Gene; Locked nucleic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002066456,0.0002948577,0.0003323947,0.0001027807,0.00004883428,0.00001509356,0.000162723,0.0003385101,0.00002410756],"category_scores_gemma":[0.00004513055,0.0002492984,0.0001910031,0.0001585882,0.0002053012,0.00002954146,0.00008787995,0.00009764667,0.000005191616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002658475,"about_ca_system_score_gemma":0.00003927958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001659959,"about_ca_topic_score_gemma":0.000001002805,"domain_scores_codex":[0.9980115,0.0001556129,0.0006501504,0.000550863,0.0003195224,0.000312367],"domain_scores_gemma":[0.9988287,0.000009966378,0.0004018775,0.0005394465,0.0001317036,0.00008828694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001331103,0.0002904696,0.0001291313,0.00002996447,0.00004219251,0.00001809224,0.00006490869,0.00007829173,0.9924533,0.00003449617,0.0006613742,0.004866702],"study_design_scores_gemma":[0.00431811,0.0003285986,0.0005360207,0.0001762282,0.0000154509,0.000006283163,0.00002806854,0.00005653342,0.9937569,0.0001702794,0.0003105429,0.0002969889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900934,0.0006845649,0.008009062,0.0002597827,0.00007651933,0.0002732863,0.0002405739,0.00002363078,0.0003392193],"genre_scores_gemma":[0.9977368,0.0008295547,0.000409155,0.0001251902,0.00006203916,0.00001701752,0.0006634943,0.00005762759,0.00009915948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007643401,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005797512422525865,"score_gpt":0.2153365565056529,"score_spread":0.2095390440831271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}