{"id":"W2561803583","doi":"10.1182/blood.v126.23.1358.1358","title":"Broad Activity of Apto-253 in AML and Other Hematologic Malignancies Correlates with KLF4 Expression Level","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"KLF4; Medicine; Cancer research; Myeloid leukemia; Leukemia; Myeloid; In vivo; Transcription factor; Biology; Internal medicine; Gene; Biochemistry; Genetics; SOX2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122811,0.0002469226,0.0003830341,0.000307158,0.0001437765,0.0002973574,0.0001369739,0.0001948365,0.002664194],"category_scores_gemma":[0.0001920665,0.0001037051,0.0002619929,0.0002056702,0.0002123074,0.0001319946,0.0001394528,0.0004201809,0.0005269329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964131,"about_ca_system_score_gemma":0.0002538943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005720551,"about_ca_topic_score_gemma":0.0008391596,"domain_scores_codex":[0.9998388,0.00001788292,0.00001925697,0.00004180782,0.00005529226,0.00002678478],"domain_scores_gemma":[0.9998707,0.00002715286,0.00002737198,0.0000130919,0.00002347322,0.00003813561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004754079,0.00007859919,0.004376519,0.00009632607,0.00002526686,0.00009326375,0.0000170288,0.0002562182,0.9870863,0.00004738345,0.0003134895,0.007134207],"study_design_scores_gemma":[0.00007215927,0.001770875,0.03404552,0.00001650719,0.00009821694,0.001331992,0.00005544977,0.001040274,0.9562151,0.00007577545,0.005265857,0.00001227412],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898976,0.00365133,0.001934783,0.0001642044,0.00004253652,0.00007504308,0.001910287,0.0001812015,0.002143058],"genre_scores_gemma":[0.9942034,0.0009782108,0.001163711,0.00009371794,0.0000127064,0.00005738301,0.001856596,0.0000156424,0.001618582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002664194,"threshold_uncertainty_score":0.008912563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04469902798381335,"score_gpt":0.2699249962252965,"score_spread":0.2252259682414832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}