{"id":"W2561804054","doi":"10.1182/blood.v124.21.4813.4813","title":"APTO-253 Induces KLF4 to Promote Potent in Vitro Pro-Apoptotic Activity in Hematologic Cancer Cell Lines and Antitumor Efficacy As a Single Agent and in Combination with Azacitidine in Animal Models of Acute Myelogenous Leukemia (AML)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Medicine; Cancer research; Azacitidine; KLF4; Leukemia; Myelodysplastic syndromes; In vivo; Myeloid leukemia; Myeloid; Bone marrow; Internal medicine; Pharmacology; Transcription factor; Biology; SOX2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001952492,0.0003033055,0.0003840495,0.0002768752,0.0001154359,0.0002017572,0.0001590668,0.0002502056,0.001915082],"category_scores_gemma":[0.00009518318,0.0001295487,0.0003268609,0.0001564757,0.000170419,0.0001430427,0.0001054472,0.000828822,0.0004148398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002471148,"about_ca_system_score_gemma":0.0002108616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005470479,"about_ca_topic_score_gemma":0.00109867,"domain_scores_codex":[0.9998754,0.00002409582,0.00001686981,0.00002020376,0.00004012067,0.00002320946],"domain_scores_gemma":[0.9999384,0.000009076759,0.00001392389,0.000008760139,0.000009052131,0.00002082807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004579203,0.0003144015,0.0001923948,0.00006801336,0.00001529842,0.00005577728,0.00001820258,0.0002776564,0.9949771,0.0001199321,0.0003275603,0.003175756],"study_design_scores_gemma":[0.0001812403,0.003255503,0.002426533,0.000008294157,0.00003488788,0.0002345249,0.00002272221,0.00130698,0.9895112,0.00005741479,0.002953537,0.000007248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910049,0.002309928,0.002378307,0.0002156863,0.0001191399,0.0001284111,0.0009808319,0.0002518338,0.002611039],"genre_scores_gemma":[0.9943503,0.0008558058,0.001437649,0.00008663311,0.00001366048,0.00008528958,0.000878266,0.00001311818,0.002279354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915082,"threshold_uncertainty_score":0.006406546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777677991474799,"score_gpt":0.2654805475534647,"score_spread":0.2477037676387167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}