{"id":"W2561804054","doi":"10.1182/blood.v124.21.4813.4813","title":"APTO-253 Induces KLF4 to Promote Potent in Vitro Pro-Apoptotic Activity in Hematologic Cancer Cell Lines and Antitumor Efficacy As a Single Agent and in Combination with Azacitidine in Animal Models of Acute Myelogenous Leukemia (AML)","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Medicine; Cancer research; Azacitidine; KLF4; Leukemia; Myelodysplastic syndromes; In vivo; Myeloid leukemia; Myeloid; Bone marrow; Internal medicine; Pharmacology; Transcription factor; Biology; SOX2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452597,0.0001732142,0.0003156424,0.0001714347,0.00001858629,0.00001942916,0.0001123649,0.0001369613,0.000001048501],"category_scores_gemma":[0.00005344105,0.0001515113,0.00001752347,0.0002294048,0.00006590776,0.0000184202,0.0001456058,0.0001502461,2.720255e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008565032,"about_ca_system_score_gemma":0.0001444699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456218,"about_ca_topic_score_gemma":0.002188942,"domain_scores_codex":[0.9987622,0.0001146431,0.0002337405,0.0004230754,0.0001558988,0.0003104063],"domain_scores_gemma":[0.9996119,0.00001873908,0.00008123369,0.0001610769,0.00005506819,0.00007196133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007770683,0.001265152,0.01638703,0.0001224703,0.00001738309,0.00003210528,0.0003024117,0.0002702592,0.9799128,0.000003289143,5.265326e-7,0.0009094718],"study_design_scores_gemma":[0.003562821,0.001310015,0.06339263,0.00009631179,0.00001337723,0.00002131596,0.00004371852,0.001003852,0.9303629,0.00002683412,0.000002009348,0.000164186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987335,0.0002594066,0.00003206231,0.000104672,0.000009105956,0.000798034,0.00001477495,0.000004671955,0.00004383099],"genre_scores_gemma":[0.999349,0.0001430383,0.0003612164,0.00001748453,0.00001051866,0.00007183939,0.00001865329,0.0000172246,0.00001101605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0495499,"threshold_uncertainty_score":0.6178453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777677991474799,"score_gpt":0.2654805475534647,"score_spread":0.2477037676387167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}