{"id":"W2561814596","doi":"10.1093/nar/gkw1294","title":"Salt-mediated two-site ligand binding by the cocaine-binding aptamer","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Aptamer; Isothermal titration calorimetry; Ligand (biochemistry); Binding site; Biophysics; Biology; Molecular binding; Biomolecule; Affinities; Nuclear magnetic resonance spectroscopy; Binding affinities; Biochemistry; Chemistry; Stereochemistry; Molecule; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001416368,0.0001976228,0.0001863765,0.0001475545,0.0004532248,0.00008298846,0.0004650972,0.0002063171,0.00001716269],"category_scores_gemma":[0.0006110119,0.0001074788,0.0001158626,0.0004917509,0.0005977573,0.00001052621,0.00035929,0.0003043232,0.0001686333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000670837,"about_ca_system_score_gemma":0.00006372314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003153696,"about_ca_topic_score_gemma":0.00002705504,"domain_scores_codex":[0.9976953,0.0002685525,0.0002505879,0.0005514654,0.0005421483,0.0006919592],"domain_scores_gemma":[0.9986881,0.0001692779,0.00007881099,0.0006549897,0.0002646374,0.0001441592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006592659,0.00003116674,0.0018447,0.000004359667,0.00005346105,0.000005129389,0.0000240919,1.033224e-7,0.9637852,0.0000254454,0.02450656,0.009653822],"study_design_scores_gemma":[0.0004671711,0.0002002422,0.0001086761,0.00004428714,0.0000113019,0.00001468354,0.00009791041,0.00002945126,0.9033923,0.00005858204,0.09538575,0.0001896998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995026,0.0002514347,0.0007448728,0.002144592,0.00005038022,0.0002243496,0.00009054271,0.00006782768,0.001400018],"genre_scores_gemma":[0.9914972,0.0007071606,0.0005138267,0.0001803701,0.0002658512,0.00001903129,0.0001072741,0.00004551742,0.00666377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07087919,"threshold_uncertainty_score":0.4382859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02542216788245466,"score_gpt":0.3420060312687452,"score_spread":0.3165838633862905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}