{"id":"W2561995968","doi":"10.1158/1538-7445.panca16-b47","title":"Abstract B47: Nanoliposomal irinotecan (nal-IRI) is an active treatment and reduces hypoxia as measured through longitudinal imaging using [18F]FAZA-PET in an orthotopic patient-derived model of pancreatic cancer","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Irinotecan; Hypoxia (environmental); Medicine; Tumor hypoxia; Pancreatic cancer; Pharmacodynamics; Pancreatic tumor; Positron emission tomography; Colorectal cancer; Cancer; Nuclear medicine; Active metabolite; Pharmacokinetics; Internal medicine; Cancer research; Chemistry; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000879192,0.0002820397,0.0002267768,0.00010728,0.00009866802,0.0001841686,0.0001248073,0.0002112348,0.001761008],"category_scores_gemma":[0.0000527697,0.00008034426,0.0001797825,0.0001054328,0.0001767189,0.0001586188,0.00007971701,0.0004774846,0.0002638273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884505,"about_ca_system_score_gemma":0.000258288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009376424,"about_ca_topic_score_gemma":0.0008795807,"domain_scores_codex":[0.9999309,0.000008019109,0.00000510355,0.00001814076,0.00002142573,0.00001634061],"domain_scores_gemma":[0.9999546,0.000008079667,0.00001239448,0.000004922928,0.000004537512,0.00001547246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005099546,0.0001310825,0.0001298852,0.00004076963,0.000004799209,0.00003412973,0.00000948553,0.00007773517,0.9974812,0.00003435728,0.00008991479,0.001456814],"study_design_scores_gemma":[0.00004043217,0.001807091,0.002386372,0.000002501534,0.00001280412,0.000141457,0.00001130005,0.000527782,0.9941067,0.000008245272,0.0009528603,0.000002550369],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969802,0.0006728496,0.0008509721,0.00007229132,0.00002325181,0.00003315727,0.0003709572,0.00004698576,0.0009492954],"genre_scores_gemma":[0.9956785,0.0004223057,0.001277869,0.00003920958,0.000006364575,0.00005478704,0.00072984,0.00001057283,0.001780504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761008,"threshold_uncertainty_score":0.005891204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1088496388803225,"score_gpt":0.3907189528198949,"score_spread":0.2818693139395724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}