{"id":"W2562019564","doi":"10.1158/1538-7445.am2015-2075","title":"Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"breakpoint cluster region; Syk; Bruton's tyrosine kinase; Cancer research; Immunoreceptor tyrosine-based activation motif; Tyrosine kinase; Signal transduction; B-cell receptor; Biology; Receptor; Tyrosine phosphorylation; Phosphorylation; Tyrosine; Cell biology; Chronic lymphocytic leukemia; Leukemia; Immunology; B cell; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009100316,0.00008397039,0.0001189274,0.0000707439,0.00007767455,0.000053692,0.0001046726,0.00013438,0.0007438656],"category_scores_gemma":[0.0002839625,0.00006538033,0.00001870844,0.0002365056,0.000100976,0.00008257089,0.00005353121,0.0002865446,0.00002756226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008317326,"about_ca_system_score_gemma":0.0004293345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000813424,"about_ca_topic_score_gemma":0.0001467153,"domain_scores_codex":[0.9988501,0.00005855078,0.0001495875,0.0002688103,0.0003811778,0.0002917777],"domain_scores_gemma":[0.9992564,0.0003231301,0.00003688999,0.00006879571,0.0002010036,0.0001137877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001900505,0.00002686156,0.01240873,0.00004005094,0.00001153256,0.000006012835,0.000251601,0.0003986614,0.9806811,0.000009720642,0.0005381943,0.005437481],"study_design_scores_gemma":[0.0008371276,0.00006543632,0.0159849,0.0001084987,0.000008523852,0.00000247923,0.0005034091,0.001996967,0.9786854,0.00139072,0.0002851045,0.0001313721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924931,0.0004036627,0.000006561445,0.0001052642,0.00002039234,0.00008036082,0.000007517021,0.00001827528,0.006864848],"genre_scores_gemma":[0.9991063,0.0001789658,0.00005049663,0.00001743528,0.0001511541,0.00008344795,0.000004155545,0.000009376214,0.0003985925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006613258,"threshold_uncertainty_score":0.8144807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1374810381576881,"score_gpt":0.3949631932884652,"score_spread":0.2574821551307771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}