{"id":"W2562019564","doi":"10.1158/1538-7445.am2015-2075","title":"Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"breakpoint cluster region; Syk; Bruton's tyrosine kinase; Cancer research; Immunoreceptor tyrosine-based activation motif; Tyrosine kinase; Signal transduction; B-cell receptor; Biology; Receptor; Tyrosine phosphorylation; Phosphorylation; Tyrosine; Cell biology; Chronic lymphocytic leukemia; Leukemia; Immunology; B cell; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382726,0.0002187437,0.0001888884,0.0003517879,0.0001086466,0.0003904307,0.0001863659,0.0002469579,0.002671931],"category_scores_gemma":[0.0001944164,0.00009181931,0.0001057633,0.0002043221,0.000257088,0.0001547477,0.0001984011,0.0004885317,0.0005041353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004353045,"about_ca_system_score_gemma":0.0001830308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000237093,"about_ca_topic_score_gemma":0.0002033147,"domain_scores_codex":[0.999846,0.00004031252,0.00001540657,0.00002057506,0.00005241838,0.0000252406],"domain_scores_gemma":[0.9999175,0.00002706411,0.00002412774,0.000004230015,0.000005236994,0.00002184015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001761127,0.0001872817,0.01008913,0.0003275487,0.00001719453,0.0003976429,0.00005295293,0.0009446058,0.9641833,0.002374627,0.0007601056,0.01890452],"study_design_scores_gemma":[0.0002184059,0.003338464,0.08942312,0.00006718859,0.0000867656,0.006216389,0.0001273385,0.004510495,0.8777699,0.002728324,0.01549291,0.00002068515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891122,0.003343161,0.00143572,0.0002283943,0.00002325943,0.00004415646,0.0004622613,0.00009381163,0.005257089],"genre_scores_gemma":[0.9971356,0.0007597358,0.0005445041,0.0000783491,0.00001548809,0.00002381836,0.0002810041,0.000009615635,0.001151802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002671931,"threshold_uncertainty_score":0.008938491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1374810381576881,"score_gpt":0.3949631932884652,"score_spread":0.2574821551307771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}