{"id":"W2562057618","doi":"10.1182/blood.v104.11.3496.3496","title":"Generation and Verification of a Three-Dimensional Model of the ALK Kinase Domain: ALK - a “Supermutant” of Abl.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Anaplastic lymphoma kinase; ABL; Protein kinase domain; Tyrosine kinase; Cancer research; Biology; Imatinib mesylate; Chemistry; Molecular biology; Imatinib; Biochemistry; Medicine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003313323,0.000539346,0.0004620137,0.0002972262,0.0005454154,0.0007606315,0.000972921,0.0008766815,0.004388391],"category_scores_gemma":[0.0005463895,0.0004423792,0.0008190594,0.0002427357,0.0002914501,0.0003626412,0.000449741,0.0007412265,0.000722374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009100582,"about_ca_system_score_gemma":0.0007959115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005555404,"about_ca_topic_score_gemma":0.003435789,"domain_scores_codex":[0.999799,0.00002616871,0.00001062106,0.00002588382,0.0001041184,0.00003420893],"domain_scores_gemma":[0.9997436,0.0000767674,0.00003873424,0.00003118176,0.00007471725,0.00003493315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003522716,0.0002858881,0.00188075,0.0004945698,0.0001071765,0.001687872,0.0003325266,0.5861119,0.3758526,0.01896061,0.003023636,0.01091034],"study_design_scores_gemma":[0.00007364419,0.0001130561,0.0005573832,0.00001610561,0.00002238936,0.0001906071,0.00006750274,0.9473606,0.04222228,0.0009868258,0.00835731,0.0000323515],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7843036,0.0007032721,0.1925882,0.0008551938,0.0002981382,0.0003470388,0.004872448,0.00206748,0.01396447],"genre_scores_gemma":[0.8696727,0.0004282187,0.1218835,0.00005819038,0.00001784485,0.000239104,0.00463949,0.0003273896,0.002733594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005555404,"threshold_uncertainty_score":0.01468062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291674528069216,"score_gpt":0.2434391095239597,"score_spread":0.2142716567170381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}