{"id":"W2562148128","doi":"10.1016/s1525-0016(16)34183-1","title":"574. Sustaining Helper-Dependent Adenoviral Vector-Mediated Human CFTR Expression in Mouse Airways Through Transient Immunosuppression","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis; Immunosuppression; Cystic fibrosis transmembrane conductance regulator; Viral vector; Genetic enhancement; Cyclophosphamide; Immunology; Gene delivery; Immune system; Vector (molecular biology); Biology; Medicine; Gene; Internal medicine; Chemotherapy; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006347459,0.0004139142,0.0003352425,0.0001510142,0.0001487087,0.00007261152,0.000633314,0.0003624812,0.00007608282],"category_scores_gemma":[0.00005479845,0.0003819762,0.000174575,0.0002498287,0.0001294149,0.00002197253,0.0001683871,0.0003880584,0.00003275521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285545,"about_ca_system_score_gemma":0.0002250283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009728958,"about_ca_topic_score_gemma":0.00007181917,"domain_scores_codex":[0.9967095,0.0005860901,0.0004522614,0.0007639961,0.0007190682,0.0007690867],"domain_scores_gemma":[0.9985697,0.00001483822,0.0001117551,0.0009030334,0.0001775852,0.0002231013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003485743,0.0003344435,0.0002651471,0.00001027691,0.00005423462,0.00009764884,0.001182358,0.0008935141,0.9916925,0.00001269082,0.0003468447,0.001624611],"study_design_scores_gemma":[0.005547112,0.003680659,0.0001890229,0.00003626871,0.000004053415,0.000008465961,0.0005679098,0.00005205635,0.9827877,0.00009227714,0.006587384,0.0004471022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890096,0.007848836,0.001519842,0.0002205313,0.0001205764,0.0006913748,0.00002355681,0.00005929287,0.0005064207],"genre_scores_gemma":[0.9973052,0.0005922847,0.0002853031,0.0005253371,0.0001250146,0.0001367441,0.0003967917,0.0001264783,0.0005068069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008904798,"threshold_uncertainty_score":0.9998632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03248132783141151,"score_gpt":0.3149867763572676,"score_spread":0.2825054485258561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}