{"id":"W2562180123","doi":"10.1212/wnl.80.7_supplement.p05.153","title":"Effect of the Sphingosine 1-Phosphate Receptor Agonist ONO-4641 on Circulating Lymphocytes in Patients with Relapsing–Remitting Multiple Sclerosis: Results from the Phase 2 DreaMS Trial (P05.153)","year":2013,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Multiple sclerosis; Medicine; Internal medicine; Placebo; Agonist; Gastroenterology; Adverse effect; Lymphocyte; Expanded Disability Status Scale; Receptor; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001206479,0.0009120717,0.001958842,0.0001981884,0.000319112,0.0005398824,0.0004803535,0.0008366988,0.00146237],"category_scores_gemma":[0.0009207175,0.0002834304,0.0009364131,0.0002197433,0.000448701,0.0005036312,0.0002350374,0.001634165,0.0002763057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003286588,"about_ca_system_score_gemma":0.0005216813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005240551,"about_ca_topic_score_gemma":0.001508538,"domain_scores_codex":[0.9994463,0.0003416686,0.00004294885,0.0000570203,0.00004031025,0.00007179954],"domain_scores_gemma":[0.9994098,0.0001747327,0.0001547435,0.00004186152,0.00003439686,0.0001844315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8218315,0.00876155,0.02336128,0.001117419,0.00303207,0.0002221689,0.0002368512,0.0007129165,0.02198519,0.0001000918,0.001421483,0.1172174],"study_design_scores_gemma":[0.4591883,0.4320437,0.09750859,0.0001423363,0.002744704,0.0006140502,0.0001967735,0.0005743442,0.004212979,0.0002080833,0.002505335,0.00006080372],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944761,0.004330624,0.00006115137,0.0001732388,0.00004188276,0.0001065667,0.0001841264,0.00001784908,0.000608547],"genre_scores_gemma":[0.9962099,0.001813909,0.0003459057,0.0003979761,0.0001517697,0.000180856,0.000408303,0.000007211091,0.0004841916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958842,"threshold_uncertainty_score":0.006380498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02625632778734737,"score_gpt":0.2673896789867118,"score_spread":0.2411333511993645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}