{"id":"W2562184463","doi":"10.1016/j.ymgmr.2016.11.006","title":"Comparing expression and activity of PCSK9 in SPRET/EiJ and C57BL/6J mouse strains shows lack of correlation with plasma cholesterol","year":2016,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism Reports","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Montreal Clinical Research Institute","funders":"","keywords":"PCSK9; LDL receptor; Kexin; Biology; Molecular biology; Proprotein convertase; Subtilisin; Promoter; Luciferase; Gene expression; Gene; Cholesterol; Lipoprotein; Genetics; Biochemistry; Transfection; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034487,0.0001349423,0.0004877631,0.00008900107,0.00002204737,0.000008384349,0.00001842306,0.00008854242,0.000001840274],"category_scores_gemma":[0.00003031329,0.00009037316,0.00004415138,0.00006293182,0.0001036078,0.00004595013,0.00005464657,0.00008425235,3.258189e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009495854,"about_ca_system_score_gemma":0.0000598949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001220783,"about_ca_topic_score_gemma":0.00004267072,"domain_scores_codex":[0.9989033,0.00005988332,0.0003102028,0.0002894614,0.0002907758,0.0001463375],"domain_scores_gemma":[0.9992356,0.000009952852,0.0002176878,0.0003408296,0.00006772733,0.0001281741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009257546,0.00006414183,0.1174045,0.0002164429,0.00006548377,0.0001018193,0.000248524,0.00009050698,0.8491488,0.00003201752,0.000001392844,0.03253384],"study_design_scores_gemma":[0.001938842,0.0001103953,0.5345091,0.0002384033,0.0001322593,0.0002610668,0.0000301043,0.0003701861,0.4620687,0.00003972579,0.0002018815,0.00009930853],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922087,0.002430051,0.004729076,0.00003380154,0.00003225992,0.0004626067,0.000005087717,0.000006367893,0.00009208084],"genre_scores_gemma":[0.997951,0.0006745241,0.001278797,0.0000185242,0.00001917714,0.00001003536,0.000002988995,0.00001848331,0.00002642865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4171046,"threshold_uncertainty_score":0.368531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091841995211696,"score_gpt":0.2564320682929093,"score_spread":0.2355136483407924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}