{"id":"W2562187388","doi":"10.1128/mcb.00522-16","title":"The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence","year":2016,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"School of Medicine, New York University; National Institutes of Health; National Cancer Institute; Samuel Waxman Cancer Research Foundation","keywords":"Ribosome biogenesis; Biology; Nucleolus; Chromatin; Cell biology; Histone; Telomere; Zinc finger; Chromatin remodeling; Senescence; Biogenesis; Ribosomal protein; Epigenetics; Ribosome; Genetics; Molecular biology; RNA; Transcription factor; DNA; Gene; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398659,0.0002891201,0.0003294764,0.0002631164,0.0001471307,0.0002174059,0.0002655922,0.0002785741,0.001153288],"category_scores_gemma":[0.0001425051,0.00008257587,0.0001698097,0.0001123484,0.0002498768,0.0001240278,0.0001595446,0.0003788531,0.0003289466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984436,"about_ca_system_score_gemma":0.0001962407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003426836,"about_ca_topic_score_gemma":0.0004834742,"domain_scores_codex":[0.999903,0.00001495567,0.000007966657,0.00002677802,0.00002006861,0.00002729211],"domain_scores_gemma":[0.9998908,0.00001327447,0.00003341901,0.00001370256,0.00001087408,0.00003795627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002523815,0.0000429203,0.000156953,0.00004522367,0.000005926949,0.00003048292,0.000006101086,0.00004782306,0.9965386,0.00007666147,0.00009852591,0.002698355],"study_design_scores_gemma":[0.00004250586,0.0004078136,0.005681472,0.000008515103,0.00001801835,0.0003127353,0.000014105,0.0007271236,0.9874949,0.00005945229,0.005227563,0.000005876068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902357,0.003559241,0.004027632,0.0001794912,0.00006484654,0.00002945933,0.0005563723,0.0003600002,0.0009871876],"genre_scores_gemma":[0.9941229,0.0008383085,0.001667018,0.00003829594,0.00001760737,0.00003023033,0.0007434031,0.00004307913,0.002498979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153288,"threshold_uncertainty_score":0.003858149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003706101535581093,"score_gpt":0.1999110617913194,"score_spread":0.1962049602557383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}