{"id":"W2562376561","doi":"10.1126/scitranslmed.aad8926","title":"Comment on “A small-molecule antivirulence agent for treating <i>Clostridium difficile</i> infection”","year":2016,"lang":"en","type":"letter","venue":"Science Translational Medicine","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Clostridium difficile; Ebselen; Microbiology; Mechanism (biology); Medicine; Biology; Chemistry; Computational biology; Antibiotics; Biochemistry; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002780429,0.00101762,0.001317242,0.000676096,0.003234097,0.002451572,0.001932755,0.05938054,0.005351458],"category_scores_gemma":[0.01665274,0.0008128998,0.001701643,0.000617411,0.002662178,0.003012332,0.001153533,0.03411353,0.007525008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00388518,"about_ca_system_score_gemma":0.003624145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006806261,"about_ca_topic_score_gemma":0.009636342,"domain_scores_codex":[0.997534,0.0005785031,0.0003618554,0.0003707129,0.0007656966,0.0003891254],"domain_scores_gemma":[0.9962506,0.001921911,0.0003977798,0.0001075618,0.000727481,0.0005946684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000107096,0.0000491766,0.0005525671,0.00005076992,0.00001655343,0.001871206,0.000084115,0.00007539934,0.0002395548,0.001469711,0.9901799,0.005303969],"study_design_scores_gemma":[0.0002784913,0.0002223164,0.002130405,0.0003525325,0.00007172789,0.002842051,0.0004178699,0.0007710732,0.0008090464,0.00759264,0.9843935,0.0001183557],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004788039,0.0008831382,0.0000982349,0.9753889,0.02072726,0.00002128581,0.00009660286,0.00005002594,0.002255832],"genre_scores_gemma":[0.001864793,0.0005422808,0.0001304458,0.9737163,0.01963999,0.0000286899,0.00003187616,0.00001659031,0.004028986],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05938054,"threshold_uncertainty_score":0.02818906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05722984777213035,"score_gpt":0.3361843136424261,"score_spread":0.2789544658702958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}