{"id":"W2562400104","doi":"10.1002/anie.201610816","title":"Discovery of a PCAF Bromodomain Chemical Probe","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Simon Fraser University","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Engineering and Physical Sciences Research Council; Genome Canada; Pfizer","keywords":"Bromodomain; PCAF; Chemistry; Subfamily; Biochemistry; Molecular biology; Histone; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008347249,0.00008885718,0.00007561802,0.00003560595,0.00001486092,0.00001303553,0.0001522429,0.00009425458,0.00008272741],"category_scores_gemma":[0.0001862763,0.00006638114,0.00008223743,0.00003746993,0.00008683878,0.00002697663,0.00006664029,0.00003268909,0.00001062024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003164669,"about_ca_system_score_gemma":0.00003552937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005340615,"about_ca_topic_score_gemma":0.00000183203,"domain_scores_codex":[0.9993091,0.00001098554,0.000185046,0.0002016019,0.0001957295,0.00009754877],"domain_scores_gemma":[0.999586,0.0000130166,0.0001044345,0.0001419779,0.000123595,0.00003094166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007480102,0.00005790511,0.0002950093,0.000006136967,0.00003016753,6.686967e-7,0.000007223839,1.139259e-7,0.9847144,0.0006099929,0.0132342,0.000969373],"study_design_scores_gemma":[0.0005738976,0.00004781909,0.0002661403,0.00005066479,0.000004899895,0.000008851483,0.000008632815,0.000001244775,0.9815408,0.0008759433,0.01652553,0.00009558101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9021135,0.0001136354,0.08536231,0.002551436,0.00105269,0.0002135731,0.0002734738,0.00002912672,0.008290267],"genre_scores_gemma":[0.9957468,0.00006849261,0.0005535899,0.0001538416,0.001138442,0.00003259848,0.0004157147,0.00001121847,0.001879301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09363331,"threshold_uncertainty_score":0.2706945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008712057150041507,"score_gpt":0.2391016371202965,"score_spread":0.230389579970255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}