{"id":"W2562400104","doi":"10.1002/anie.201610816","title":"Discovery of a PCAF Bromodomain Chemical Probe","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Simon Fraser University","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; European Federation of Pharmaceutical Industries and Associations; Wellcome Trust; Engineering and Physical Sciences Research Council; Genome Canada; Pfizer","keywords":"Bromodomain; PCAF; Chemistry; Subfamily; Biochemistry; Molecular biology; Histone; Cancer research; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502447,0.0002720981,0.0001531646,0.000172752,0.0002061737,0.000212711,0.0004031638,0.0004330488,0.002070823],"category_scores_gemma":[0.0002051455,0.0001538279,0.0002208343,0.0001441419,0.0002179609,0.0001814074,0.000302745,0.0005318629,0.0006769645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005143194,"about_ca_system_score_gemma":0.000348782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007520742,"about_ca_topic_score_gemma":0.0009893087,"domain_scores_codex":[0.9998599,0.00002243436,0.000004305281,0.00003280101,0.00003649382,0.00004401487],"domain_scores_gemma":[0.9999391,0.00001152527,0.00001151161,0.000007621595,0.00001285914,0.00001737529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009980846,0.00004732759,0.00009207967,0.00008591834,0.000007702556,0.00009944475,0.00003930647,0.00041784,0.988308,0.00188221,0.0004776283,0.00844279],"study_design_scores_gemma":[0.00003933171,0.0004289219,0.0003051033,0.000006110513,0.000007250755,0.0001857751,0.00001176128,0.0008683565,0.984473,0.0001561308,0.01350767,0.00001046766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.886807,0.006375642,0.07230885,0.001417257,0.0001358794,0.0004322741,0.001415722,0.0007138838,0.03039351],"genre_scores_gemma":[0.9695752,0.003061228,0.0181569,0.0004556633,0.0000247489,0.0001372001,0.0007724327,0.00002894079,0.007787813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002070823,"threshold_uncertainty_score":0.00692755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008712057150041507,"score_gpt":0.2391016371202965,"score_spread":0.230389579970255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}