{"id":"W2562443556","doi":"10.1182/blood.v116.21.3273.3273","title":"Phase 2 Study of MLN8237, An Investigational Aurora A Kinase (AAK) Inhibitor In Patients with Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndromes (MDS)","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Common Terminology Criteria for Adverse Events; Medicine; Internal medicine; Neutropenia; Phases of clinical research; Adverse effect; Oncology; Multiple myeloma; Leukemia; Clinical trial; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001293608,0.001451921,0.001140995,0.0003447792,0.0002789877,0.0005793643,0.0005943559,0.000855652,0.004143941],"category_scores_gemma":[0.0006404305,0.000528623,0.0007821085,0.0003202027,0.0005030831,0.0005912486,0.0003192468,0.001798986,0.0008730053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000753639,"about_ca_system_score_gemma":0.001571162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008734,"about_ca_topic_score_gemma":0.003262726,"domain_scores_codex":[0.9997128,0.0001443388,0.00001451103,0.00005104659,0.00002234506,0.00005495093],"domain_scores_gemma":[0.9996444,0.00005291551,0.00006540414,0.0000261957,0.00002678077,0.0001842132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6744288,0.09967983,0.01640538,0.001273297,0.001397162,0.0006720964,0.0005239343,0.003692186,0.0641689,0.0005194611,0.008628197,0.1286107],"study_design_scores_gemma":[0.6154984,0.354551,0.01880808,0.00005526105,0.0003644337,0.0004454804,0.00007097082,0.001804452,0.003561533,0.0002399464,0.004573388,0.00002702291],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912167,0.001924179,0.0004778484,0.0004159069,0.00008900557,0.002631006,0.001159915,0.00009040186,0.001995201],"genre_scores_gemma":[0.9884197,0.001293213,0.001644849,0.0007772957,0.0001170805,0.002572978,0.002382174,0.00002339406,0.002769342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004143941,"threshold_uncertainty_score":0.01386291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006878014787305713,"score_gpt":0.2340636134460563,"score_spread":0.2271855986587506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}