{"id":"W2562564284","doi":"10.1158/1538-7445.am2015-727","title":"Abstract 727: Signaling redundancy between EGFR and c-Met: molecular analysis of concurrent inhibition of c-Src and therapeutic potential against prostate cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Gefitinib; DU145; Crizotinib; Cancer research; Epidermal growth factor receptor; EGFR inhibitors; Proto-oncogene tyrosine-protein kinase Src; Lapatinib; Tyrosine kinase; Dasatinib; Growth factor receptor; C-Met; Pharmacology; Biology; Medicine; Cancer; Prostate cancer; Receptor; Lung cancer; Hepatocyte growth factor; Internal medicine; Breast cancer; Trastuzumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009549155,0.0002050613,0.0001953954,0.0001495019,0.00009624263,0.0001674323,0.0002205681,0.0001625156,0.00166131],"category_scores_gemma":[0.00004762044,0.00009061729,0.000201298,0.000166437,0.0001201121,0.0001050602,0.0000751385,0.0004501641,0.0002485664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00026872,"about_ca_system_score_gemma":0.00024398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000841052,"about_ca_topic_score_gemma":0.001390506,"domain_scores_codex":[0.9999264,0.000008530628,0.00000452166,0.000008986814,0.00003084774,0.00002065315],"domain_scores_gemma":[0.9999692,0.000005583366,0.000006586516,0.000002262339,0.000005705517,0.00001061969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00017882,0.00005763388,0.00009430334,0.0000412987,0.000008241391,0.00004044302,0.000004834037,0.0001021208,0.9979379,0.0001149569,0.00006086196,0.001358659],"study_design_scores_gemma":[0.00004258359,0.001277174,0.00299041,0.000004299543,0.00003285572,0.0003407199,0.0000126681,0.000976637,0.9917929,0.00002501167,0.00250069,0.000004130373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914215,0.003563463,0.001334782,0.0001463435,0.0000308762,0.00006900607,0.0004380464,0.00004222752,0.002953775],"genre_scores_gemma":[0.9951758,0.001232457,0.001109091,0.00003208601,0.000008690376,0.00002533284,0.0004784886,0.000005507663,0.001932587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166131,"threshold_uncertainty_score":0.005557597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.104109410838805,"score_gpt":0.4303421882291572,"score_spread":0.3262327773903522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}