{"id":"W2562656615","doi":"10.1182/blood.v106.11.4639.4639","title":"A Phase I Study of the Histone Deacetylase Inhibitor MGCD0103 (MG-0103) Given as a Three-Times Weekly Oral Dose in Patients with Leukemia or Myelodysplastic Syndromes (MDS).","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Pharmacology; Myelodysplastic syndromes; Nausea; Pharmacodynamics; Pharmacokinetics; Adverse effect; Phases of clinical research; Oncology; Gastroenterology; Clinical trial; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000975074,0.001100064,0.001353154,0.0003889785,0.000393397,0.0007535754,0.001012912,0.001010668,0.002222075],"category_scores_gemma":[0.0006768804,0.0004913245,0.0009566448,0.0004385978,0.001095083,0.0005527381,0.0003191595,0.003167739,0.0006674879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000857783,"about_ca_system_score_gemma":0.001404963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178437,"about_ca_topic_score_gemma":0.00240932,"domain_scores_codex":[0.99965,0.0001614083,0.00001846086,0.00005407826,0.0000320361,0.00008396256],"domain_scores_gemma":[0.9994045,0.00009660267,0.0001034821,0.00006145817,0.0000286285,0.0003053258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4912444,0.1971252,0.01133369,0.0007875241,0.0008066646,0.0006885412,0.0006364492,0.003700663,0.1609125,0.0006420683,0.004973163,0.127149],"study_design_scores_gemma":[0.3165804,0.6574373,0.012804,0.00002244199,0.0002099836,0.0003236606,0.00006817242,0.001394957,0.008660738,0.0001598183,0.002312833,0.00002569444],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950961,0.0006905214,0.0005247709,0.0002824267,0.00007620103,0.00176658,0.000490209,0.00006868909,0.001004539],"genre_scores_gemma":[0.9923226,0.00076577,0.001876465,0.0006252292,0.0001070425,0.001637744,0.001191445,0.00002114907,0.001452546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222075,"threshold_uncertainty_score":0.007433534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014362270707804,"score_gpt":0.2777129898355881,"score_spread":0.2675693671285101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}