{"id":"W2562717999","doi":"10.1158/1538-7445.panca16-b13","title":"Abstract B13: Novel treatment strategy for pancreatic cancer by targeting the ‘undruggable’ Ras oncoprotein","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; GTPase; Cancer research; Biology; Protein tyrosine phosphatase; Pancreatic cancer; Signal transduction; Phosphorylation; Tyrosine phosphorylation; Anti-apoptotic Ras signalling cascade; Small GTPase; Cell growth; Tyrosine kinase; Receptor tyrosine kinase; Tyrosine; Cancer; Cell biology; Biochemistry; Genetics; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073254,0.0003266518,0.0003527922,0.0003343548,0.0002068173,0.0002951985,0.0003585953,0.0004025355,0.003596575],"category_scores_gemma":[0.00004255545,0.0001059514,0.0002889346,0.0003251728,0.0001737693,0.0002489183,0.0002346747,0.0007263546,0.0007831417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568205,"about_ca_system_score_gemma":0.0002575871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004019147,"about_ca_topic_score_gemma":0.0007175759,"domain_scores_codex":[0.9999601,0.000005803813,0.000003179103,0.0000100265,0.000009870661,0.00001098086],"domain_scores_gemma":[0.9999821,0.000001806538,0.000003445346,0.000002124645,0.000002303779,0.000008241861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003391071,0.002126623,0.001666682,0.001013564,0.0001521602,0.001585604,0.00008760372,0.001189432,0.7820433,0.002035534,0.006426626,0.1982818],"study_design_scores_gemma":[0.00265497,0.01659837,0.02193187,0.0001812704,0.0005774826,0.007068366,0.000178345,0.006240099,0.7616933,0.001303805,0.1814941,0.00007812039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318926,0.02476055,0.02288245,0.001534087,0.0005766258,0.0005392626,0.001088631,0.0007829884,0.01594275],"genre_scores_gemma":[0.963455,0.01310902,0.009928175,0.0008016468,0.0001032002,0.0002316248,0.00149675,0.00006381745,0.01081059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003596575,"threshold_uncertainty_score":0.01203173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07634599836698992,"score_gpt":0.4007290450485935,"score_spread":0.3243830466816036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}