{"id":"W2562898571","doi":"10.1158/1538-7445.panca16-a84","title":"Abstract A84: PDAC initiation and progression occurs more rapidly from KrasG12D-expressing ductal cells than KrasG12D-expressing acinar cells in the absence of Trp53","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pancreatic Intraepithelial Neoplasia; Ductal cells; Cancer research; Carcinogenesis; Acinar cell; KRAS; Pathology; Biology; Epigenetics; Cell; Pancreatic cancer; Medicine; Pancreas; Cancer; Pancreatic ductal adenocarcinoma; Immunohistochemistry; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001597137,0.0002788212,0.0004588055,0.0006971343,0.0002772432,0.0005703404,0.0002242808,0.0005221835,0.01080755],"category_scores_gemma":[0.0002105315,0.0002335488,0.0004876953,0.0003287732,0.0002294979,0.0003124442,0.0004072628,0.001261484,0.003495334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421171,"about_ca_system_score_gemma":0.000192272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000654789,"about_ca_topic_score_gemma":0.0004517148,"domain_scores_codex":[0.9996899,0.00002263201,0.00003723574,0.00008300501,0.0001042987,0.00006300925],"domain_scores_gemma":[0.9996653,0.00004801552,0.00008189243,0.00005327847,0.00003673146,0.0001148796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004111361,0.00007997829,0.00125162,0.00004937268,0.00000976616,0.0001717522,0.0000140287,0.00002805356,0.9953272,0.0001199177,0.0003557697,0.002181424],"study_design_scores_gemma":[0.00008978119,0.0008003935,0.05414488,0.00002345807,0.00003857403,0.003133736,0.00008274431,0.000842661,0.9252726,0.000144682,0.01540856,0.00001799211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821771,0.002042213,0.004272125,0.0003909601,0.0001272389,0.0001087758,0.004520606,0.0006219186,0.005739041],"genre_scores_gemma":[0.9811467,0.0007088881,0.00168917,0.0001573357,0.00001904337,0.0001135037,0.004348043,0.0001336599,0.01168368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01080755,"threshold_uncertainty_score":0.03615487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09018492482267111,"score_gpt":0.4399566863209091,"score_spread":0.349771761498238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}