{"id":"W2562945845","doi":"10.1038/ncomms13943","title":"An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Ubiquitin ligase; Cell division control protein 4; Phosphopeptide; Chemistry; Plasma protein binding; Binding site; Biophysics; Allosteric enzyme; Ubiquitin; Biochemistry; Phosphorylation; Cell biology; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009914,0.0001321065,0.0001379808,0.00008643731,0.0001513266,0.0002915176,0.0003289632,0.0001276105,0.001237092],"category_scores_gemma":[0.0001568474,0.0001556832,0.00009090454,0.00005022125,0.0002405472,0.0001953919,0.0003336278,0.0002038118,0.0002697542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684703,"about_ca_system_score_gemma":0.000117339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002181709,"about_ca_topic_score_gemma":0.0003730178,"domain_scores_codex":[0.9999417,0.00000706721,0.00000269741,0.00001390016,0.00001905959,0.00001546041],"domain_scores_gemma":[0.9999321,0.00001568831,0.0000146468,0.00001007161,0.000005976873,0.00002159104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008396796,0.00001976634,0.0003985052,0.00001744905,0.00000289523,0.00007202834,0.00001222549,0.0005713471,0.9960324,0.0008105662,0.000062798,0.001916073],"study_design_scores_gemma":[0.00003033283,0.0001498268,0.002748888,0.000003809816,0.00000869731,0.0002317049,0.00003197641,0.03522587,0.959315,0.0004229689,0.001821167,0.000009769262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956762,0.00009668634,0.003265979,0.0000434564,0.000007691387,0.000004176745,0.00001256548,0.00008574477,0.0008075327],"genre_scores_gemma":[0.9991609,0.00002250938,0.0004926291,0.00000845028,0.000001448725,0.000001856223,0.000009288272,0.000004848157,0.0002981379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237092,"threshold_uncertainty_score":0.00413847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03093361767258968,"score_gpt":0.322828291515616,"score_spread":0.2918946738430264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}