{"id":"W2562988259","doi":"10.1093/neuonc/now188.180","title":"P08.47 Dianhydrogalactitol (VAL-083) causes bifunctional alkylation leading to irreparable DNA double-strand breaks, S/G2 phase cell-cycle arrest and tumor cell death in an MGMT independent manner offering a unique treatment paradigm for GBM","year":2016,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada); University of British Columbia","funders":"","keywords":"Cell cycle checkpoint; Double strand; Cell cycle; Cell biology; DNA; Programmed cell death; Cancer research; DNA repair; Chemistry; Biology; Cell; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001481318,0.0003401907,0.0001374047,0.0001400321,0.0001356753,0.0001780561,0.0002002243,0.0002213554,0.001817916],"category_scores_gemma":[0.00007808742,0.00008497012,0.0001609433,0.000137631,0.0001526191,0.000165176,0.0001930914,0.0004336518,0.0006027013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001750969,"about_ca_system_score_gemma":0.0002554388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006279917,"about_ca_topic_score_gemma":0.0007108932,"domain_scores_codex":[0.9999151,0.00001591869,0.000005531876,0.00001357198,0.00002578669,0.00002419674],"domain_scores_gemma":[0.9999626,0.000003885099,0.0000106513,0.000005305705,0.000007766439,0.000009878709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001641275,0.0001014332,0.0003174109,0.00008220088,0.000006318469,0.0000955401,0.00001805681,0.00009957117,0.9900193,0.0003283845,0.0004368559,0.008330669],"study_design_scores_gemma":[0.0000268956,0.0006410792,0.002071024,0.000004760513,0.00001650371,0.0003156768,0.00001611994,0.0003866577,0.9826415,0.00005990879,0.01381494,0.000004822272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762958,0.006215462,0.007871822,0.0005350725,0.0001639344,0.0001804207,0.001399976,0.0002289693,0.007108438],"genre_scores_gemma":[0.9727352,0.00564464,0.004870241,0.0001880701,0.0000499848,0.00008297549,0.002952438,0.00004720205,0.01342926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001817916,"threshold_uncertainty_score":0.006081522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03600810494761814,"score_gpt":0.3269535239535203,"score_spread":0.2909454190059022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}