{"id":"W2563225587","doi":"10.1016/j.tcb.2016.11.009","title":"RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling","year":2016,"lang":"en","type":"review","venue":"Trends in Cell Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Krembil Foundation","funders":"Medical Research Council; Cancer Research UK","keywords":"Biology; Downstream (manufacturing); Cell biology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001508269,0.0005600615,0.0009220548,0.0003156688,0.00005696603,0.00002108231,0.0003950894,0.0009248657,0.0001511491],"category_scores_gemma":[0.00006206577,0.0004112481,0.0002934431,0.0002471631,0.0002822191,0.000003532209,0.000261869,0.0002262907,0.00001757413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004670415,"about_ca_system_score_gemma":0.0001319251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006363086,"about_ca_topic_score_gemma":0.000005061979,"domain_scores_codex":[0.9974816,0.0003865076,0.0006345502,0.0009857237,0.00008835136,0.0004232365],"domain_scores_gemma":[0.9987504,0.00007156564,0.0003303731,0.0006644407,0.00004663444,0.0001365483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002475115,0.00002765876,0.00008417229,0.0008842355,0.0001106095,0.00002465986,0.00002083388,0.000007052542,0.02715396,0.000333684,0.0002384661,0.9710899],"study_design_scores_gemma":[0.0007057167,0.0002058541,0.000011249,0.001217886,0.0002045679,0.00003452899,0.000006636665,0.000004287754,0.01456399,0.000953463,0.9812772,0.0008145968],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00667492,0.9908316,0.00006996941,0.000009343036,0.000242989,0.0001969344,0.0001406847,0.00002493083,0.00180869],"genre_scores_gemma":[0.03997138,0.9565908,0.0003675914,0.00005260689,0.0003501748,0.0000752963,0.001965229,0.00008159203,0.0005453539],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9810387,"threshold_uncertainty_score":0.9998339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02195323608993714,"score_gpt":0.3121305773530622,"score_spread":0.2901773412631251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}