{"id":"W2563241643","doi":"10.1038/ncomms13719","title":"Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Helmut Horten Stiftung; Pfizer","keywords":"PTEN; Prostate cancer; Notch signaling pathway; Prostate; Cancer research; Cancer; Senescence; Medicine; Biology; Signal transduction; PI3K/AKT/mTOR pathway; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534203,0.0001503343,0.0002334854,0.0001134023,0.0001708522,0.00001070377,0.0002900723,0.000168944,0.00003554698],"category_scores_gemma":[0.00009489552,0.00009675438,0.00008334584,0.000378919,0.0002475998,0.0001263137,0.0001912328,0.0004468181,0.00001357473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544169,"about_ca_system_score_gemma":0.0002419198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004188903,"about_ca_topic_score_gemma":0.00008977149,"domain_scores_codex":[0.9987846,0.0000843508,0.0002791404,0.0002461891,0.0003361182,0.0002695854],"domain_scores_gemma":[0.9980476,0.0001496801,0.000146842,0.001147605,0.0003890119,0.0001192878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001691697,0.0002951346,0.008598624,0.00006565621,0.00004344721,0.000004978697,0.0004781929,0.000004161237,0.9652323,0.0002355629,0.0009917795,0.02388105],"study_design_scores_gemma":[0.003795203,0.0001819033,0.006821088,0.001314588,0.0000678534,0.00000521322,0.0001589877,0.0001862269,0.9116658,0.00006605305,0.0755089,0.0002281624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9142867,0.05878459,0.0002877503,0.02215903,0.0002404608,0.00163721,0.0005949489,0.0001306344,0.001878717],"genre_scores_gemma":[0.9840851,0.01353489,0.0007677056,0.00009986977,0.00002740371,0.0002446797,0.0001917031,0.00002415087,0.001024492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07451712,"threshold_uncertainty_score":0.3945529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01968602185403748,"score_gpt":0.3239933997795439,"score_spread":0.3043073779255064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}