{"id":"W2563248625","doi":"10.1093/biomethods/bpw002","title":"Variations in 5-methylcytosine and 5-hydroxymethylcytosine among human brain, blood, and saliva using oxBS and the Infinium MethylationEPIC array","year":2016,"lang":"en","type":"article","venue":"Biology Methods and Protocols","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Pfizer Canada; Canadian Institutes of Health Research; Genome Canada; National Institutes of Health; National Institute on Drug Abuse; Fondation Fyssen; American Foundation for Suicide Prevention","keywords":"5-Hydroxymethylcytosine; 5-Methylcytosine; DNA methylation; Bisulfite; Bisulfite sequencing; Biology; Computational biology; Epigenetics; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003236295,0.0002359531,0.0003680942,0.0001207384,0.0002509764,0.00005448318,0.00009114325,0.0003287062,0.000008117221],"category_scores_gemma":[0.000834577,0.0001457959,0.00003775004,0.0001339395,0.0007931876,0.00001650151,0.000171625,0.0001261521,1.309135e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006570267,"about_ca_system_score_gemma":0.00003279199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001545899,"about_ca_topic_score_gemma":0.00007828035,"domain_scores_codex":[0.9971501,0.001562699,0.0004336567,0.0005377717,0.00005833248,0.0002575048],"domain_scores_gemma":[0.9986534,0.000674063,0.0002141632,0.000288022,0.00007231826,0.00009806172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008208997,0.00002482594,0.09185547,0.00002414961,0.00004813445,2.830774e-7,0.0001057966,0.000001024011,0.8923508,0.002655319,0.000002547615,0.01284958],"study_design_scores_gemma":[0.009245729,0.001096655,0.2622618,0.0001421116,0.0001342925,0.00002592277,0.00005208964,0.0002202153,0.6720564,0.04368208,0.01045051,0.0006322305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8892569,0.003297885,0.09744784,0.0009481784,0.00003456209,0.00885426,0.00001705033,0.00001152668,0.0001317839],"genre_scores_gemma":[0.9049686,0.000762807,0.08931581,0.0002074604,0.0001955484,0.004384131,0.00002005121,0.00003200421,0.000113637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2202944,"threshold_uncertainty_score":0.5945383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03168567328432487,"score_gpt":0.3945483664648352,"score_spread":0.3628626931805103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}